0:00
Hi, I'm Professor Salvadori
from the University of Florence.
In this first part of my talks
on IgA nephropathy,
I will brief you about
its epidemiology
and physiopathology.
0:19
Let me show you
the agenda of the day.
And let me start
with the definition
and the main characteristics
of this disease.
0:35
IgA nephropathy
represents the most frequent
glomerulonephritis.
The typical histological sign
is a proliferation
of glomerular mesangial cells
with different aspects
on light microscopy,
that we'll see later.
The hallmark is the deposition
of IgA and complement
mainly in the mesangial area.
And finally,
the disease is characterized
by extremely different
clinical signs.
1:15
Here, you may have a look
of the different aspects
on light microscopy.
Accordingly,
you'll understand easily
that light microscopy
is not useful
for a right diagnosis.
1:33
Here you see,
on the right-hand side
of the slide,
the hallmark of the disease
that is the deposition of IgA
as may be observed
looking at immunofluorescence.
