Hello, my name is Geoffrey Pitt.
And the title of my presentation
is "Precision Medicine and Cardiology."
United States President, Barack Obama,
announced in his State of the Union address in January of 2015
that he was launching an effort to emphasize
a Precision Medicine Initiative
and said that the fruits of such efforts
would be in areas such as cancer and diabetes.
While investigators have been building
on new genomic technologies for over a decade to bring
precision medicine close practice, this attention from a U.S. President
has greatly increased the focus of many thought leaders,
such as indicated by this highlighted editorial
from the current and former directors
of the National Institutes of Health that soon followed
the president's announcement.
As highlighted in President Obama's address,
a lot of attention for precision medicine
has focused on diabetes and cancer.
But cardiovascular diseases remain the number one killer
in the United States.
Is there a role for precision medicine in cardiology?
My goal today will be to convince you that precision medicine
certainly will affect cardiology.
In fact, while many of the mutation-specific cancer therapies
have received a disproportionate amount of the recent attention
focused on precision medicine,
cardiology has been an unrecognized leader, in my opinion,
in the development in precision medicine,
and will continue to do so.
So first, let me set the stage.
What exactly is precision in medicine?
In this slide you will see several different definitions.
Clearly, if looking at all of these, the concept of precision medicine is fluid.
But the general theme captured by all of these definitions
is that as clinicians our ultimate goal is to treat our patients individually,
aiming for the right drug in the right dose
at the right time.