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1. Introduction
2. Why the presentation is relevant to this series
3. What is a "founder effect"?
4. Founder effect: very important concept
5. Aim of presentation
6. A brief population history
7. Where is Qubec?
8. Present day occupation of the Qubec territory
9. French Canadian settlement 1608-1900
10. The French Canadian founder effect
11. France vs. British isles immigration
12. The "register de la population du Qubec ancient''
13. Pioneer immigration according to origin
14. Genetic contribution to population development
15. Demand for descendants
16. Founding immigration during French rule period
17. Importance of time of arrival
18. Founding immigration during French rule period
19. Importance of time of arrival
20. The XXth century population vs. its founders
21. The BALSAC population register
22. Genealogical reconstruction
23. Basic characteristics of the genealogical sample
24. Completeness of genealogies, per generation
25. Identification of subjects with common ancestors
26. Founders distribution by origin and marriage period
27. Cumulative genetic contribution of founders (%)
28. Distribution and genetic contribution of founders
29. Genetic contribution of French founders
30. The Quebec regional gene pools
31. What happened after the British conquest?
32. The Saguenay region
33. Major Mendelian diseases in Saguenay
34. Quebec regional populations
35. Inbreeding
36. Mean inbreeding coefficients at the 4th generation
37. Mean inbreeding coefficients at the 13th generation
38. Study of the genetic heritage of Gaspesians
39. Colonization of the Gaspe Peninsula
40. Place of residence of the Gaspesian subjects
41. Kinship calculations
42. Kinship within each group of subjects
43. Diversity of maternal \ paternal lineages (Gaspesia)
44. Maternal lineages among Gaspesians
45. Paternal lineages among Gaspesians
46. The French-Canadian founder effect impact
47. Regional pattern of the French-Canadian gene pool
48. Dominant diseases in the French Canadians
49. Recessive diseases in French Canadians
50. Genetic disorders prevalent in French Canadians
51. Diseases with new founder effects in Quebec
52. HSAN2 disease
53. Identification of few mutations in the same gene
54. T14484C Leber optic atrophy mutation in Quebec
55. Conclusion

Topics Covered

• Founder effect
• Population history and the French Canadian founder effect
• The contemporary population in relation to its founders
• Regional gene pools: the examples of the Saguenay and the Gaspesie regions
• Regional distribution of disease mutations

Links

Series:

• Human Population Genetics I

Categories:

• Diseases, Disorders & Treatments
• Genetics & Epigenetics

Therapeutic Areas:

• Cardiovascular & Metabolic
• Immunology & Inflammation
• Neurology
• Oncology

Talk Citation

Brais, B., Desjardins, B., Labuda, D., St-Hilaire, M., Tremblay, M. and Vezina, H. (2007, October 1). The genetics of French Canadians [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 27, 2020, from https://hstalks.com/bs/322/.

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Bernard Brais has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Bertrand Desjardins has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. Damian Labuda has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Marc St-Hilaire has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. Marc Tremblay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Prof. Helene Vezina has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.