• The Human Genome Project
• 28 min
  1. Major gene families in humans and their evolutionary history

  • Prof. Yoshihito Niimura
• 41 min
  2. Evolution of human mitochondrial DNA variations

  • Prof. Toomas Kivisild
• 51 min
  3. Ethical issues in human population genetics

  • Prof. Henry Greely
• Important Phenotypic Phenomena
• 56 min
  4. Genetics of breast and ovarian cancer

  • Prof. Jeffrey Weitzel
• 53 min
  5. Colorectal cancer and the rare variant hypothesis

  • Prof. Sir Walter Bodmer
• Archived Lectures *These may not cover the latest advances in the field
• 32 min
  6. The genetics of breast and ovarian cancer

  • Dr. Piri Welcsh
• 37 min
  7. Historical and geographical genetic variation: Europe

  • Prof. Antonio Torroni
• 40 min
  8. Linguistic evolution

  • Dr. Merritt Ruhlen
• 37 min
  9. Human microsatellite and minisatellite DNA polymorphisms

  • Dr. James Weber
• 41 min
  10. Human population genetics: lifespan

  • Prof. Kaare Christensen
• 33 min
  11. Major gene families in humans and their evolutionary history

  • Prof. Yoshihito Niimura
  • Prof. Masatoshi Nei
• 34 min
  12. Natural selection and sequence polymorphism

  • Prof. Austin Hughes
• 32 min
  13. Human Y chromosome phylogenetics and phylogeography

  • Prof. Peter Underhill
• 63 min
  14. The peopling of the Americas: new insights from genetic studies

  • Dr. Theodore Schurr
• 48 min
  15. History and geography of human genetic diversity I

  • Prof. Luigi Luca Cavalli-Sforza
• 40 min
  16. History and geography of human genetic diversity II

  • Prof. Luigi Luca Cavalli-Sforza
• 24 min
  17. History and geography of human genetic diversity III

  • Prof. Luigi Luca Cavalli-Sforza
• 46 min
  18. The HapMap project

  • Prof. Andrew Clark
• 37 min
  19. Genetic diseases in the Jewish population

  • Prof. Neil Risch
• 48 min
  20. The genetics of French Canadians

  • Dr. Bernard Brais
  • Dr. Bertrand Desjardins
  • Prof. Damian Labuda
  • Dr. Marc St-Hilaire
  • Prof. Marc Tremblay
  • Prof. Helene Vezina
• 33 min
  21. Human genetic variation of Africa

  • Prof. Joanna Mountain
• 66 min
  22. Evolution: how genes and their variation got here

  • Prof. Kenneth Weiss
• 20 min
  23. Modern human origins

  • Prof. Richard Klein
• 64 min
  24. The human genomes

  • Prof. Gil McVean
• 49 min
  25. The signature of local adaptations in human polymorphism data

  • Dr. Anna Di Rienzo
• 37 min
  26. Genetics of Pakistani populations in an Asian and global context

  • Prof. S. Qasim Mehdi
• 38 min
  27. Cultural evolution

  • Prof. Marcus Feldman
• 45 min
  28. The genetic component to diabetes

  • Dr. Nancy Cox
• 39 min
  29. Human population structure

  • Prof. Noah Rosenberg

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Jewish history and genetics
3. Jewish roots and diaspora
4. Babylonian exile
5. Under the Persians
6. After the Roman expulsion
7. Modern times
8. Classification of Jews
9. Jewish subgroups
10. Genetic diseases
11. Population distributions
12. Population specificity
13. Diseases found in Ashkenazim
14. Lysosomal storage diseases (1)
15. Lysosomal storage diseases (2)
16. Diseases in Ashkenazim - four LSDs
17. Genetic drift
18. Heterozygote advantage (selection)
19. Hemoglobinopathies
20. Malaria
21. Arguments for selection
22. Arguments for drift
23. Other diseases affect Ashkenazim
24. Other diseases in Ashkenazim
25. Comparing diseases by group
26. LSDs versus non-LSDs
27. Expected patterns
28. Geographic disparities
29. Ordered frequencies for LSD mutations
30. Ordered frequencies for non-LSD mutations
31. Mutation frequencies
32. Dating mutations
33. Number of generations
34. Dating of various mutations
35. Times of origin
36. LSD and non-LSD are similar
37. Geographic distributions
38. Diseases tested
39. Data analyzed
40. Geographic categories
41. Mutation frequencies for LSDs
42. Mutation frequencies for non-LSDs
43. Frequency of TSD 1421
44. Difference in distribution of LSDs and non-LSDs
45. The TSD-1277 mutation distribution
46. The TSD-1421 mutation distribution
47. The origin of the TSD mutation
48. The genetic drift: explanation for these mutations
49. Conclusions concerning the AJ LSD mutations
50. Bottlenecks in the Jewish population
51. Three bottlenecks
52. Selection versus drift

Topics Covered

• Jewish history and genetics
• Classification of Jews
• Genetic diseases found in Jews, particularly Ashkenazi Jews
• Lysosomal storage diseases
• Natural selection (heterozygote advantage) vs. genetic drift
• Mutation frequencies, ages and geographic distributions
• Bottlenecks in Jewish history

Links

Series:

• Human Population Genetics I

Categories:

• Clinical Practice
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 28, 2025

Financial Disclosures

• Prof. Neil Risch has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.