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Printable Handouts
Navigable Slide Index
- Introduction
- Bacteria-inhibiting nano materials
- Nanostructured silicon nitride
- Silicon nitride: 3 months (bacteria inoculation)
- Electrophoretic deposition
- Images of different electrophoretic deposited coats
- S. aureus (SA) growth on different sized coats
- P. aeruginosa (PA) growth on different sized coats
- Amp.resistant E. coli growth on nanotextured coat
- Using nanoscale radio-opaque agents
- SA: PU nano BaSO4 to reduce bacteria functions
- PA: PU nano BaSO4 to reduce bacteria functions
- Pure polymers and other bacteria
- Vortex experiment nanomodified
- Nanostructured selenium (Se) for reducing bacteria
- Nanostructured selenium coating on paper towels
- Nanostructured selenium coating (results)
- Se coated materials: Ti/stainless steel/UHMWPE
- SEM of silk with 100 nm SeNP
- S. aureus attachment and growth on selenium
- Antibacterial efficacy of free MgO
- MgO increases osteoblast adhesion
- Nanomedicine laboratory (Vascular)
- Vascular metals
- Titanium & vascular endothelial cell proliferation
- Nanomedicine laboratory (Bladder)
- Nano-structured PGA increases tissue regeneration
- Greater rat bladder regeneration with nano PGA
- Future direction: fighting Ebola with nanotechnology
- Discussion
- Dream for the future of nanomedicine
- Thank you
- Acknowledgements
Topics Covered
- Bacteria-inhibiting nano materials
- Nanostructured silicon nitride
- Electrophoretic deposition
- Nanoscale radio-opaque agents
- Pure polymers and bacteria
- Nanostructured selenium coating
- Antibacterial efficacy of free magnesium oxide (MgO)
- Titanium & vascular endothelial cell proliferation
- Nano-structured PGA & tissue regeneration
- Fighting Ebola with nanotechnology
Talk Citation
Webster, T.J. (2015, September 30). Nanomedicine: promises and pitfalls 3 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/URYE9734.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Thomas J. Webster has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Nanomedicine: promises and pitfalls 3
Published on September 30, 2015
36 min
Other Talks in the Series: Nanomedicine
Transcript
Please wait while the transcript is being prepared...
0:04
DR. THOMAS J. WEBSTER, Ph.D.:
I'll make a little bit of a transition
to talking, now, more
about medical devices.
So how can we use
nanomedicine to keep bacteria
from growing on medical devices?
And I mentioned this
earlier that this
is a huge problem because
infection of implants
are actually increasing,
not decreasing.
And, again, this is because our
approach to kill bacteria to date
has been to develop
pharmaceuticals or antibiotics.
And these antibiotics are
killing the bacteria initially,
but eventually the bacteria develop
a resistance to these antibiotics.
So we think in nanomedicine
that this approach is flawed.
And we really cannot keep on
developing new antibiotics to kill
bacteria because they
are going to constantly
mutate and develop a resistance to
the antibiotics that we develop.
We think nanomaterials, or
nanomedicine, has a huge promise
for killing bacteria,
for keeping bacteria
from attaching to a surface.
So I'm about to talk about a
particular chemistry called silicon
nitride, in which you
can basically take
the surface of a radio-opaque
material, like silicon nitride,
and create nano-scale
features on that material
to keep bacteria from attaching.
This is initially an approach
that we came up with
to promote radio-opacity.
If, again, you think about
the original argument we made
for nanomaterials,
their novelty resides
in their increased surface area.
So if you take a material
that is radio-opaque
and you increase its
surface area, you actually
will increase radio-opacity.
It'll show up much
brighter on an x-ray
simply by increasing nanoscale
features on the surface.
One question we then
asked is, that's great,
We can increase
radio-opacity, but how
do cells respond to these
increased surface area materials,
to these materials that
have nanoscale features?