0:00
My name is Sirinrath Sirivisoot.
I am actually a lecturer
of biological engineering,
and faculty of engineering at King
Mongkut University of Technology
in Thonburi in Bangkok, Thailand.
This talk is one of the contributions in
Nanometers in Theory, entitled
Implantable Nanosensors.
0:20
This talk will follow as
shown in this outline.
First I will talk about a
challenge of orthopedic implants,
the future of personalized
medicine for medical devices,
and the current supporting
technologies from nanoscience
and nanotechnology.
Then I will introduce our
idea of the closed-loop sensing
and drug release using medical device,
and how we develop an in
situ orthopedic sensor,
and voltage controlled
drug delivery coding.
And finally I will end with
conclusions and future directions.
0:54
The lifetime of orthopedic
implants is about 10 to 20 years.
Some device is failing at high
rates within a few years instead
of lasting 10 years or more.
The main reasons of
the implant failure
could be from
infection, inflammation,
causing swelling and pain,
osteolysis,
active bone resorption, involving wear particles,
worn from the contact surface.
Osteomyelitis, inflammation that is caused
by infection or implant loosening
form fibroblast tissue formation.
When a patient needs to a undergo
revision surgery some of the bills
were about US $400,000 in charges
related to hospitalization,
and an added US $28,000 in doctors bills.
Today human lifespan also
increased all around the world,
therefore there is still a
high need for better bone
growing material in the market.
