Other Talks in the Series: Nanomedicine

My name is Sirinrath Sirivisoot. I am actually a lecturer of biological engineering, and faculty of engineering at King Mongkut University of Technology in Thonburi in Bangkok, Thailand. This talk is one of the contributions in Nanometers in Theory, entitled Implantable Nanosensors.
This talk will follow as shown in this outline. First I will talk about a challenge of orthopedic implants, the future of personalized medicine for medical devices, and the current supporting technologies from nanoscience and nanotechnology. Then I will introduce our idea of the closed-loop sensing and drug release using medical device, and how we develop an in situ orthopedic sensor, and voltage controlled drug delivery coding. And finally I will end with conclusions and future directions.
The lifetime of orthopedic implants is about 10 to 20 years. Some device is failing at high rates within a few years instead of lasting 10 years or more. The main reasons of the implant failure could be from infection, inflammation, causing swelling and pain, osteolysis, active bone resorption, involving wear particles, worn from the contact surface. Osteomyelitis, inflammation that is caused by infection or implant loosening form fibroblast tissue formation. When a patient needs to a undergo revision surgery some of the bills were about US $400,000 in charges related to hospitalization, and an added US $28,000 in doctors bills. Today human lifespan also increased all around the world, therefore there is still a high need for better bone growing material in the market.