0:00
Good morning everyone.
My name is Dr. Kumar, and I
am the principal investigator
and the Director of the
Nanomedicine Research Laboratory
in the Department of Medical
Laboratory Science in the college
of health University of Delaware.
Today I'm going to give a talk on
scaffold technology used to repair
the damaged cardiovascular tissues.
0:25
After a cardiac event, the proper
treatment and care of the damaged
tissue is crucial in restoring
the optimal cardiac function
and preventing future
cardiac events.
Which is very difficult
to achieve, so recently we
have developed an approach to using
very high tech tissue engineering.
And in this approach, recently, we
have used thymosin beta four, which
we found played a very significant,
vital role in cardiac health,
and development by
regulating angiogenesis,
inflammatory responses,
and wound healing.
Literature has shown that the
43-amino acid protein, which
is called thymosin beta 4, acts as
a sequestering G-actin monomers,
and subsequently effecting the
actin-cytoskeletal organization
necessary for the cardiac
cell motility, organogenesis,
and other cellular,
and crucially when
which is necessary for
the repair of the heart.
1:33
I'd like to give you
a little introduction
about the nanomedicine, which
is the area of my expertise.
Nanomedicine therapies occurs
in the scale of one nanometer
to 100 nanometers.
So many molecules, which we
have present in our body,
or in the environment, or in
the systems, are in nanoscale.
For example, water, glucose,
antibodies, virus, bacteria.
These all are in a
nanoscale, and material,
from antibodies to viruses,
are very common in our body.
And then many nanomaterials, like
nanopores, dendrimers, nanotubes,
quantum dots, nanoshells, all
of these nanoscale materials,
have been used for a
long time in the research
and for various drug
delivery and therapies.
