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Thymosin β4 coated nanofiber scaffolds for the repair of damaged cardiovascular tissue
Published on May 4, 2015 22 min
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Good morning everyone. My name is Dr. Kumar, and I am the principal investigator and the Director of the Nanomedicine Research Laboratory in the Department of Medical Laboratory Science in the college of health University of Delaware. Today I'm going to give a talk on scaffold technology used to repair the damaged cardiovascular tissues.
After a cardiac event, the proper treatment and care of the damaged tissue is crucial in restoring the optimal cardiac function and preventing future cardiac events. Which is very difficult to achieve, so recently we have developed an approach to using very high tech tissue engineering. And in this approach, recently, we have used thymosin beta four, which we found played a very significant, vital role in cardiac health, and development by regulating angiogenesis, inflammatory responses, and wound healing. Literature has shown that the 43-amino acid protein, which is called thymosin beta 4, acts as a sequestering G-actin monomers, and subsequently effecting the actin-cytoskeletal organization necessary for the cardiac cell motility, organogenesis, and other cellular, and crucially when which is necessary for the repair of the heart.
I'd like to give you a little introduction about the nanomedicine, which is the area of my expertise. Nanomedicine therapies occurs in the scale of one nanometer to 100 nanometers. So many molecules, which we have present in our body, or in the environment, or in the systems, are in nanoscale. For example, water, glucose, antibodies, virus, bacteria. These all are in a nanoscale, and material, from antibodies to viruses, are very common in our body. And then many nanomaterials, like nanopores, dendrimers, nanotubes, quantum dots, nanoshells, all of these nanoscale materials, have been used for a long time in the research and for various drug delivery and therapies.