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JOHN PETRIE: I'm John Petrie.
I'm professor of diabetic
medicine at the University
of Glasgow in the UK.
This presentation is
about Type 1 Diabetes,
Control and Complications Trials.
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The complications of diabetes
that have been established
over many years are shown on the
left-hand side of this slide,
and the more recently recognized
ones are on the right.
The complications that we
will be focusing on today
are those of myocardial
infarction and stroke,
sometimes known as the
macrovascular complications,
which can also include
peripheral vascular disease.
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The slide here shows a study by
Krolewski, which compared the rates
of mortality in the Pittsburgh
cohort of people with type 1
diabetes, with those in
the Framingham cohort,
looking at mortality over
different age groups.
And from this slide,
published in 1987,
you can see that the rates of
mortality in people with type 1
diabetes were very high.
And this was mainly due to coronary
artery disease in comparison
with non-diabetic,
healthy individuals
in the Framingham cohort.
This is a case in men and women.
And the relative risk of
mortality at any particular age,
you'll see in this slide, is
really massively elevated up
to 20-fold in some age groups, and
particularly high in young women
in whom the background
rates in the population
are, of course, very low.
