Type 1 diabetes: control and complications trials

Published on August 31, 2015   44 min

Other Talks in the Series: Diabetes in Perspective

0:00
JOHN PETRIE: I'm John Petrie. I'm professor of diabetic medicine at the University of Glasgow in the UK. This presentation is about Type 1 Diabetes, Control and Complications Trials.
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The complications of diabetes that have been established over many years are shown on the left-hand side of this slide, and the more recently recognized ones are on the right. The complications that we will be focusing on today are those of myocardial infarction and stroke, sometimes known as the macrovascular complications, which can also include peripheral vascular disease.
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The slide here shows a study by Krolewski, which compared the rates of mortality in the Pittsburgh cohort of people with type 1 diabetes, with those in the Framingham cohort, looking at mortality over different age groups. And from this slide, published in 1987, you can see that the rates of mortality in people with type 1 diabetes were very high. And this was mainly due to coronary artery disease in comparison with non-diabetic, healthy individuals in the Framingham cohort. This is a case in men and women. And the relative risk of mortality at any particular age, you'll see in this slide, is really massively elevated up to 20-fold in some age groups, and particularly high in young women in whom the background rates in the population are, of course, very low.
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Type 1 diabetes: control and complications trials

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