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Printable Handouts
Navigable Slide Index
- Introduction
- The problem
- The limit to resolution of pedigree studies
- Possible solution
- Theory of two loci
- Linkage equilibrium
- Linkage disequilibrium
- Linkage disequilibrium measures
- No recombination: SNPs A and B mutations
- No recombination: only three gametes
- Genealogical interpretation of D'=1
- Statistical significance of LD
- Decay of LD over time
- Linkage disequilibrium change and random drift
- LD and recombination rate equilibrium relation
- Linkage disequilibrium decays across a gene
- Linkage disequilibrium is rare beyond 100 kb or so
- The linkage disequilibrium beyond 500 Kb
- LD means the sites are likely to be close together
- LD patterns examination by testing all sites' pairs
- Different human populations different levels of LD
- The international HapMap project
- LD decay across the genome HapMap
- Heterogeneity of LD across the genome
- Recombination hotspots can break LD blocks
- Hotspots of recombination
- Tag SNPs increase efficiency in studies
- SNPs proportion in phase I HapMap with tag SNP
- Using the HapMap website (1)
- Using the HapMap website (2)
- Using the HapMap website (3)
- Macular degeneration and CFH
- Age-related macular degeneration
- Transformative technology
- Design of GWAS
- Ongoing GWAS studies
- The wellcome trust case control consortium (1)
- The wellcome trust case control consortium (2)
- dbGaP
- Etiology or prediction? Drugs or diagnostics?
- Etiology
- Use of ability to predict disease risk
- One DNA test gets you your perfect vitamin pack
- The future paradigm: the 4 P's
Topics Covered
- The problem in pedigree analysis
- A possible solution for the resolution limitations in pedigree analysis
- Theory of two loci
- Linkage equilibrium and disequilibrium
- Recombination events between SNPs
- Genealogical interpretation
- Statistical significance of LD
- The effect of random drift on linkage disequilibrium
- Variability of LD among different populations
- Heterogeneity of LD across the genome
- Hotspots of recombination
- Tag SNPs
- The HapMap website
- Design of GWAS
- Welcome Trust Case Control Consortium
- Etiology
Talk Citation
Clark, A. (2007, October 1). The HapMap project [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/ZEQN7784.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Andrew Clark has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.