My name is Christian Roux.
I am a professor of Rheumatology
in the Paris Descartes
University in Paris, France.
And the topic today is about
bone loss and osteoporosis
in patients with
Here are my disclosures,
related to this talk.
Glucocorticoids are very
effective in a number of diseases
with acute or chronic inflammation.
At any time, roughly 1%
of the world population
is receiving oral glucocorticoids,
and the highest prevalence of use
is in patients at the age of 70.
That is to say, we are underlying
quite high risk of osteoporosis.
Glucocorticoids therapy is
the most common
cause of secondary osteoporosis.
This is a theoretical curve of
change in bone strength in patients
receiving such a treatment.
As you can appreciate, the
decrease is rapid and dramatic
within the first year, and
maybe during the first month
after initiating the treatment.
And then, this decrease occurs
more slowly, there after.
This rapid effect is
parallel with the risk
of fractures, which
after the initiation of therapy.
And there is a strong rationale
for this effect, related
to both the underlying
effect of inflammation,
that we will see on one the slides,
but also the effect of steroids on bone
through direct or