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RIKARD HOLMDAHL:
This material is intended
to describe the use of animal
models for rheumatoid arthritis.
The expected audiences: scientists
in both academia and industry that
want to use animal modeled
for rheumatoid arthritis
for validating drug
treatments or re-investigating
basic mechanisms at
the genesis of arthritis
or basic mechanisms in inflammation.
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To start with, I will review
rheumatoid disease itself,
rheumatoid arthritis
and then go through
with the different available models,
and then have some discussions
on how to best use these models.
So rheumatoid arthritis
is a common disease.
It actually affects 0.5% to
1% of the world population.
It's spread all over the world.
It comes in all ages, and
it is a quite modern disease
actually, a few hundred years old.
And the cause is unknown.
We know it's a chronic disease.
It's lifelong, and it's developed
as an uncontrolled inflammation.
It mainly affects
peripheral joints,
and a typical sign is that it destroys
the joint architecture, cartilage,
and bone.
Also, it has some systemic
manifestation as well.
In particular, in more
severe disease cases.
Importantly, this
is a disease that is
defined with a certain set of criteria
of different symptoms and signs.
And it's probably
more proper to call it
a syndrome with a
number of different,
so far undefined subtypes.
This is of course important
considering animal models
since animal models are by
definition, something we create
ourselves, and it's more defined.
So it might only represent
subtypes of rheumatoid arthritis,
