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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Genetic admixture processes
- What is genetic admixture?
- Allele frequencies in admixed populations
- Genetic distances between the source populations
- Approach to complex admixture processes
- Probability of locus source population origin
- Locus origin at any generation
- Expectation, variance and higher moments
- Example: a single event of admixture
- Admixture example when s1=s2 at g=1
- Admixture at further generations when s1=s2
- Example: asymetric founding
- Time since founding admixture event
- Genetic admixture processes: conclusions
- Isolation, migration & sociocultural behavior
- Human admixture: a complex process
- Sources of reproductive isolation among humans
- Admixture among populations throughout evolution
- Admixture under influence of socio-cultural rules
- Encounters leading to admixture in the Americas
- Admixture in Native Americans
- Variable sources and levels of genetic admixture
- Admixture in the context of Neolithic transitions
- Humans and Neanderthals: possible admixture
- Admixture: a process through time and space
Topics Covered
- Genetic admixture processes
- Statistical approach to allele frequencies in admixed populations
- General mechanistic approach to complex admixture processes
- Human admixture: isolation, migration and sociocultural behavior
- Genetic admixture in the evolutionary history of Homo sapiens
Talk Citation
Verdu, P. (2015, April 21). Human admixture 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 6, 2024, from https://doi.org/10.69645/EVWP9798.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Paul Verdu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Human admixture 1
Published on April 21, 2015
37 min
Other Talks in the Series: Human Population Genetics II
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Paul Verdu.
I am a tenured researcher
at the CNRS
hosted at the Museum of Mankind
in Paris, France,
and today I am going to talk to you
about human admixture.
0:13
[Genetic admixture processes:
a population genetics perspective]
We will first investigate
genetic admixture processes
from a theoretical
and a population genetics perspective.
Then, we will talk and investigate
human admixture as a phenomenon
through isolation,
migration, and in particular,
sociocultural behavior.
Finally, we will illustrate
these points
with the case study
of genetic admixture
between "Pygmy"
and "non-Pygmy" populations
from Central Africa.
0:42
Genetic admixture processes:
a population genetics perspective.
0:49
What is genetic admixture?
Admixture between populations
can be classically defined
as exchanges of genes
between two
or more previously
reproductively isolated populations.
In this cartoon,
you can see population one
and population two,
which we will call source populations.
They are isolated,
but at some point in time—
time, T here—
they send migrants, or genes,
with proportion s1 and s2
in this cartoon,
with s1 plus s2 equals one,
to form a third population
that we'll denote as admixed.
In particular, admixed individuals
have a fraction of their genome,
denoted H, that is derived
from the gene pool
of one
of the previously isolated source populations.
Be careful here—admixed individuals,
per se, are individuals
who have a fraction of their genome
coming from each one
of the source populations,
so H for the admixed individual
is between zero and one.
The admixed population, per se,
can withhold individuals
that are not genetically admixed
but that are just migrants
from the first
or the second source population.