Hello, I'm Trevor Pemberton,
a Professor of Biochemistry
and Medical Genetics
at the University of Manitoba.
Today I'm going to talk
about the influence
of cultural and population
processes on patterns of identity
by descenting human populations
and their importance
in understanding human evolutionary
history and phenotypic variation.
I will start by defining
what identity by descent is
and the population and cultural
processes that give rise to it.
Next, I will introduce the
inbreeding coefficient as a measure
of identity by descent
levels in individual genomes,
the pedigree and genomic
estimators used to calculate it,
and give an overview of its patterns
in worldwide human populations,
and how these reflect their
different cultures and histories.
Then I will introduce
runs of homozygosity
as an approach to detect
identity by descent regions
in individual genomes, and how
inbreeding coefficient estimates
based upon this approach
correlate with those obtained
with the genomic estimator.
Finally, I'll review some recent
findings on genomic patterns
in runs of homozygosity in worldwide
human populations, their utility
for understanding human
and briefly outline their importance
in human phenotypic variation.