• The Apoptotic Pathway in Humans
• 36 min
  1. Mitochondria and apoptosis

  • Prof. Stephen Tait
• Clinical Application of Apoptosis Research
• 31 min
  2. Targeting apoptosis pathways in cancer therapy

  • Dr. Simone Fulda
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  3. Targeting apoptosis pathways in cancer therapy

  • Dr. Irene Ghobrial
• 20 min
  4. Apoptotic pathways in mammals

  • Prof. Douglas Green
• 46 min
  5. Lysosomal cell death pathways: new possibilities for cancer therapy

  • Prof. Marja Jaattela
• 57 min
  6. Degradation of apoptotic cells

  • Prof. Shigekazu Nagata
• 61 min
  7. Signaling during engulfment: the beginnings of a good meal

  • Prof. Kodi Ravichandran
• 29 min
  8. Apoptotic cell clearance deficiencies

  • Prof. Martin Herrmann
• 46 min
  9. Caspase inhibitors in drug discovery

  • Dr. Tom O'Brien
• 28 min
  10. Mitochondria in apoptosis

  • Prof. Jean-Claude Martinou
• 52 min
  11. Apoptosis in C. elegans

  • Prof. Michael Hengartner
• 46 min
  12. Regulation of apoptosis: lessons from Drosophila and their implications for human health and disease

  • Prof. Hermann Steller
• 29 min
  13. The death receptor signalling pathway

  • Dr. Richard Siegel
• 24 min
  14. The Bcl-2 family

  • Dr. David Huang
• 43 min
  15. Caspases

  • Prof. Yuri Lazebnik
• 44 min
  16. Mechanisms of apoptosis from structural biology

  • Prof. Yigong Shi
• 64 min
  17. p53 and apoptosis

  • Prof. Moshe Oren
• 47 min
  18. The p53 family: function and molecular mechanisms

  • Prof. Gerry Melino
• 37 min
  19. Natural caspase inhibitors

  • Prof. Guy Salvesen
• 27 min
  20. TRAIL-induced apoptosis: from analysis of the death-inducing signalling complex (DISC) to clinical applicability

  • Dr. Henning Walczak
• 34 min
  21. Autophagic cell death

  • Prof. Eric Baehrecke
• 28 min
  22. Phagocytosis of apoptotic cells

  • Prof. Peter Henson
• 62 min
  23. Apoptosis in the immune system

  • Prof. Peter Krammer
• 68 min
  24. Apoptosis in the nervous system

  • Prof. Pierluigi Nicotera
• 49 min
  25. Endothelial cell apoptosis

  • Prof. Richard Kolesnick

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Overview: apoptosis pathways in cancer therapy
3. The apoptosis pathways
4. The intrinsic and extrinsic pathways
5. Extrinsic pathway: Fas
6. Bcl-2 in the intrinsic pathway (1)
7. Bcl-2 in the intrinsic pathway (2)
8. Pro/anti-apoptotic members of the Bcl-2 family
9. The final pathway: caspases
10. Regulation of the Apoptotic pathways
11. Pathways that regulate apoptosis (1)
12. p53
13. Ubiquitin/proteosome pathway
14. Aggresome
15. NF-kappa B characteristics (1)
16. NF-kappa B characteristics (2)
17. PI3K/Akt pathway
18. PI3K/Akt
19. mTOR
20. PKC
21. Heat shock proteins (1)
22. Heat shock proteins (2)
23. Regulators of the apoptosis pathways
24. Pathways that regulate apoptosis (2)
25. Agents that target the extrinsic pathway
26. Agents that target the intrinsic pathway
27. Agents that target the mitochondrial membrane
28. Agents that target Bcl-2 (1)
29. Agents that target Bcl-2 (2)
30. Agents that target the common pathway
31. Inhibitors of apoptosis modulators (1)
32. Inhibitors of apoptosis modulators (2)
33. Inhibitors of p53
34. Proteosome inhibitors (1)
35. Proteosome inhibitors (2)
36. Aggresome inhibitors
37. Inhibitors of the PI3K pathway
38. PKC inhibitor
39. Heat shock proteins
40. NF-kappa B inhibitors
41. Summary

Topics Covered

• Apoptosis pathways
• Pathways regulating the intrinsic and extrinsic pathways
• ovel therapeutic agents in cancer therapy that target the apoptosis pathways and the modulators of apoptosis

Links

Series:

• Apoptosis

Categories:

• Cancer
• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on January 15, 2020

Financial Disclosures

• Dr. Irene Ghobrial has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.