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- Evolution of the Apoptotic Pathway
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52 min
1. Apoptosis in C. elegans- Prof. Michael Hengartner
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46 min
- The Apoptotic Pathway in Humans
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29 min
3. The death receptor signalling pathway- Dr. Richard Siegel
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36 min
4. Mitochondria and apoptosis- Prof. Stephen Tait
- Apoptosis Molecules
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24 min
5. The Bcl-2 family- Dr. David Huang
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43 min
6. Caspases- Prof. Yuri Lazebnik
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37 min
7. Natural caspase inhibitors- Prof. Guy Salvesen
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44 min
8. Mechanisms of apoptosis from structural biology- Prof. Yigong Shi
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27 min
- Clearance of Apoptotic Cells
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28 min
10. Phagocytosis of apoptotic cells- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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34 min
11. Autophagic cell death- Prof. Eric Baehrecke
- Apoptosis and Disease
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64 min
12. p53 and apoptosis- Prof. Moshe Oren
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47 min
13. The p53 family: function and molecular mechanisms- Prof. Gerry Melino
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62 min
14. Apoptosis in the immune system- Prof. Peter Krammer
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68 min
15. Apoptosis in the nervous system- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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49 min
16. Endothelial cell apoptosis- Prof. Richard Kolesnick
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31 min
17. Targeting apoptosis pathways in cancer therapy- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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42 min
18. Targeting apoptosis pathways in cancer therapy- Dr. Irene Ghobrial
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20 min
19. Apoptotic pathways in mammals- Prof. Douglas Green
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46 min
20. Lysosomal cell death pathways: new possibilities for cancer therapy- Prof. Marja Jaattela
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57 min
21. Degradation of apoptotic cells- Prof. Shigekazu Nagata
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61 min
22. Signaling during engulfment: the beginnings of a good meal- Prof. Kodi Ravichandran
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29 min
23. Apoptotic cell clearance deficiencies- Prof. Martin Herrmann
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46 min
24. Caspase inhibitors in drug discovery- Dr. Tom O'Brien
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28 min
25. Mitochondria in apoptosis- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Overview: apoptosis pathways in cancer therapy
- The apoptosis pathways
- The intrinsic and extrinsic pathways
- Extrinsic pathway: Fas
- Bcl-2 in the intrinsic pathway (1)
- Bcl-2 in the intrinsic pathway (2)
- Pro/anti-apoptotic members of the Bcl-2 family
- The final pathway: caspases
- Regulation of the Apoptotic pathways
- Pathways that regulate apoptosis (1)
- p53
- Ubiquitin/proteosome pathway
- Aggresome
- NF-kappa B characteristics (1)
- NF-kappa B characteristics (2)
- PI3K/Akt pathway
- PI3K/Akt
- mTOR
- PKC
- Heat shock proteins (1)
- Heat shock proteins (2)
- Regulators of the apoptosis pathways
- Pathways that regulate apoptosis (2)
- Agents that target the extrinsic pathway
- Agents that target the intrinsic pathway
- Agents that target the mitochondrial membrane
- Agents that target Bcl-2 (1)
- Agents that target Bcl-2 (2)
- Agents that target the common pathway
- Inhibitors of apoptosis modulators (1)
- Inhibitors of apoptosis modulators (2)
- Inhibitors of p53
- Proteosome inhibitors (1)
- Proteosome inhibitors (2)
- Aggresome inhibitors
- Inhibitors of the PI3K pathway
- PKC inhibitor
- Heat shock proteins
- NF-kappa B inhibitors
- Summary
Topics Covered
- Apoptosis pathways
- Pathways regulating the intrinsic and extrinsic pathways
- ovel therapeutic agents in cancer therapy that target the apoptosis pathways and the modulators of apoptosis
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Ghobrial, I. (2007, October 1). Targeting apoptosis pathways in cancer therapy [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/299/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Irene Ghobrial has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
