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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- The lethal effect of radiation in mammalian tissues
- Sphingomyelin
- Metabolic pathway of ceramide
- Smase in the endothelium of proximal aorta
- Radiation-induced endothelial apoptosis
- Villus/crypt unit of the small intestine
- Tissue damage & lethality of mice after RT
- Differential effect of BM transplantation
- Apoptosis in irradiated GI villae
- Apoptotic endothelial cells in the lamina propria
- Endothelial apoptosis & GI syndrome
- bFGF abrogates cell death after WBR
- bFGF treatment delays death induced by radiation
- RT-induced apoptosis is inhibited in asmase KO
- Endothelial & paneth cells express FGFR mRNA
- Direct and indirect effects of radiation
- Growth patterns of transplanted tumors
- Effect of RT on 129 transplanted fibrosarcomas
- RT-induced microvascular endothelial apoptosis
- Fibrosarcomas implanted into asmase-/- mice
- Growth pattern of B16F1 melanoma and BAX
- Marrow derived cells contribute to angiogenesis
- WT vs. asmase KO donors in WT recipients
- Bone marrow transplanted from KO to WT mice
- asmase KO and WT and endothelial apoptosis
- Isolated asmase-/- tumoral endothelial cells and RT
- The two-target model for single-dose radiotherapy
- Future directions/ongoing studies
- HIF-1 - master regulator of hypoxia-response
- Radiation-induced reoxygenation & HIF-1-alfa
- HIF-1 knockdown sensitizes tumor to RT
- Inhibition of HIF-1 is done post RT
- The vascular componant of tumor response to RT
- Collaborators
Topics Covered
- Endothelial apoptosis
- Role in tumor response to radiation therapy
- Tissue damage results from depletion of stem cells and cells with clonogenic capacity
- Radiation targets the DNA leading to reproductive (mitosis-associated) or apoptotic cell death
- Modifications of DNA damage recognition and repair pathways determine the level of tissue sensitivity to radiation
- Sphingomyelin
- Ceramide
- GI tract and bone marrow: very radiation responsive
- Growth patterns of tumors
- The two-target model for single-dose radiotherapy of experimental tumors
- Engaging the vascular component of tumor response to radiation
Talk Citation
Kolesnick, R. (2007, October 1). Endothelial cell apoptosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/296/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Richard Kolesnick has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.