Immunosuppressive mechanisms in myeloid cells

Published on December 2, 2014   49 min

Other Talks in the Series: Immunotherapy of Cancer

Other Talks in the Series: Macrophage Heterogeneity and Function

Hi. My name is Dimitry Gabrilovich. I am head of the Tumor Immunology Program in Wistar Institute and Professor to University of Pennsylvania in Philadelphia. I am going to talk to you about myeloid-derived suppressor cells in tumors.
What we'll discuss, the following topics today. First, we will discuss a definition of myeloid-derived suppressor cells, then the main characteristics, followed by molecular mechanisms regulating myeloid-derived suppressor cell expansion, and mechanism of myeloid-derived suppressor cell activity, primarily, the inhibitory effect on T cells. We will talk about therapeutic targeting of myeloid-derived suppressor cells in cancer at the end of the presentation.
Myeloid cells with immunosuppressive features have been known since the late '70s. Investigators describe appearances of these cells in response to stimulation with different growth factors. The first evidence that these cells could be involved in tumor development or associated with the tumor development have been recorded in mid-90s. And they become the focus of more intensive studies in early 2000. The term of myeloid-derived suppressor cells has been introduced in 2007. And these days, these cells become the focus of intensive studies by many groups in different conditions, primarily in cancer.

Immunosuppressive mechanisms in myeloid cells

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