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1. Introduction
2. Apoptosis in development
3. Delayed removal of interdigital webs
4. Anti-APO-1-induced DNA ladder
5. Synchronized apoptosis in a culture
6. The death receptors
7. Two CD95 signaling pathways
8. Necrosis versus apoptosis
9. 3D model of CD95 receptor
10. CD95 DISC formation
11. c-FLIP-L/S inhibit caspase-8 activation
12. c-FLIP-L/S inhibit CD95-mediated apoptosis
13. The CD95 signaling pathway in MCF7-Fas cells
14. The immune response
15. AICD upon TCR-restimulation
16. IL-2 initiated switch regulates apoptosis sensitivity
17. IL-2 is required for efficient apoptosis of d6 T cells
18. Influence of IL-2 on DISC formation in d6 T cells
19. Influence of IL-2 on mitochondria in d6 T cells
20. CD95 resistance and sensitivity model in T cells
21. CD28 reduces CD3 induced apoptosis
22. CD28 costimulation upregulates c-FLIP-S in ATCs
23. CD28 costimulation upregulates Bcl-xL in ATCs
24. CD28 costimulation represses CD95L promoter
25. Modulation of CD95 pathway by CD28
26. Memory markers and subclasses of memory cells
27. In vitro culture system
28. Sensitivity of long-term T cells towards apoptosis
29. Proliferation assay
30. Determination of apoptosis: a healthy control
31. Determination of apoptosis: a sepsis patient
32. Septic patients lymphocytes are resistant to CD95
33. Increased T-cell apoptosis in septic patients
34. The T cell response defines survival in sepsis
35. Why apoptosis?
36. Rodent stroke model
37. Abs for CD95L and TNF attenuate stroke damage
38. Better locomotor response of Abs-treated animals
39. Spinal cord injury and MRI diagnostics
40. Spinal cord injury model
41. MRI of injured mice
42. Apoptosis after SCI
43. Apoptosis decsreses by anti-CD95L-Ab
44. Short-term experiments
45. Swimming test
46. Summary
47. Swimming test after spinal cord injury in mice
48. Dream of a tumor immunologist
49. Killer cells meet a tumor cell
50. Chemotherapy and p53-induced apoptosis (1)
51. Mutations of the p53-gene
52. p53 mutants do not transactivate the CD95-gene
53. A model for the action of chemotherapeutic drugs
54. Chemotherapy and p53-induced apoptosis (2)
55. Tumor regression induced by anti-APO-1

Topics Covered

• Basics of apoptosis
• Signalling through death receptors
• Apoptosis in the immune system
• Apoptosis in diseases: sepsis, stroke and spinal cord injury
• Apoptosis and killer T cells
• Apoptosis and p53
• Apoptosis and cancer

Links

Series:

• Apoptosis

Categories:

• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Peter Krammer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.