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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Apoptosis
- Extrinsic and intrinsic apoptosis pathways
- How cancer cells escape apoptosis
- Caspase-independent pathways
- Death by more than thousand cuts
- Introduction to lisosomes and lysosomal cell death
- Lysosomes - forgotten ''suicide bags'' (1)
- The intracellular dynamic trafficking of lysosomes
- Lysosomes - forgotten ''suicide bags'' (2)
- LMP: lysosomal membrane permeabilization
- Signals leading to LMP
- Effect of microtuble destabilizing agents
- Effect of DNA damaging
- Lysosome cell death pathways study problems
- Detection of LMP: lysosomal pH gradient
- Blue light induces rapid lysosomal leakage
- Detection of LMP using green light
- Detection of LMP: immunostaining
- Detection of LMP: enzymatic activity measurement
- Lysosomal changes in cancer
- Transformation of murine embryonic fribroblasts
- Lysosomal Transformation-associated changes
- MEFs sensitivity to cathepsin-dependent cell death
- Transformation and sensitivity to photooxidation
- How cancer cells escape lysosomal cell death?
- Siramesine - a drug that targets lysosomes
- Siramesine - a sigma-2 receptor ligand
- Siramesine induces apoptosis-like cell death
- Transformation sensitizes NIH 3T3 cells to the drug
- Oral administration of siramesine
- Siramrsine does not induce classic apoptosis
- Siramesine disrupts the lysosomal pH gradient
- Involvement of cystein cathepsins
- Siramesine induces cathepsin release in vitro
- Lysosomes as targets for future cancer therapy
- Thanks
- Thanks to the apo-lab-Copenhagen
Topics Covered
- Cell death in cancer
- Introduction to the lysosomes and lysosomal cell death
- Lysosomal changes in cancer
- Siramesine, a drug that targets lysosomes and kills cancer cells in vitro and in vivo
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Jaattela, M. (2007, October 1). Lysosomal cell death pathways: new possibilities for cancer therapy [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/289/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Marja Jaattela has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.