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1. Introduction
2. Apoptosis induction by TRAIL
3. TRAIL: a member of the TNF superfamily
4. TNF-related apoptosis-inducing ligand (TRAIL)
5. TRAIL-R belong to the TNF-R superfamily
6. The death receptors
7. The TRAIL system
8. TRAIL DISC formation
9. c-FLIPS/c-FLIPL inhibit TRAIL-mediated apoptosis
10. Caspase 10
11. Caspase-10 is recruited to CD95 and TRAIL
12. Caspase-10 cannot substitute caspase-8
13. Caspase-10 protein expression is lost in tumors
14. Isoforms of caspase-10 and caspase-8
15. No differential cleavage for RIP and TRAF-1
16. Caspase-3 is cleaved by caspase-8 and -10
17. Caspase-8 and -10 generates different proteins
18. Summary and conclusion (caspase-8 versus -10)
19. Death receptors
20. The TRAIL system: can we kill tumor cells?
21. LZ-TRAIL induces apoptosis in tumor cell lines
22. Effect of TRAIL on normal human cells in vitro
23. TRAIL treatment of a subcutaneous tumor
24. Efficacy of TRAIL treatment in tumors
25. Inhibition of etoposide-induced apoptosis by Bcl-x
26. Double hit on tumor cells
27. Safety of TRAIL treatment: alone and in synergy
28. TRAIL versus CD95L in vivo
29. Sensitivity of PHH to TRAIL and to CD95L
30. Sensitivity and resistancy of PHH to TRAIL
31. HepG2 sensitivity to various forms of TRAIL
32. PHH are sensitive to one form of TRAIL only
33. Sensitisation of PHH by chemotherapeutics
34. Summary and conclusion (TRAIL on PHH)
35. What determines TRAIL sensitivity vs. resistance?
36. Sensitivity of various Hep cells to TRAIL
37. Proteasome inhibitors sensitise HC for TRAIL
38. Proteasome inhibition: TRAIL-induced apopotosis
39. Proteasome inhibition results in NF-kB inhibition
40. Proteasome inhibitors: upregulation of TRAIL-R1,2
41. TRAIL upregulation unnecessary for sensitisation
42. Proteasome inhibition enhances TRAIL formation
43. TRAIL sensitisation at the DISC level
44. Crosstalk between the two death pathways
45. Division of apoptosis regulation (DO40)
46. Thank you

Topics Covered

• poptosis induction by the TNF-related apoptosis-inducing ligand (TRAIL)
• Apoptosis-inducing TNF super-family ligands and receptors
• Formation of the deathinducing signalling complex (DISC)
• Caspase-8 versus caspase-10
• Synergy of TRAIL with chemotherapeutics
• Tumour specificity of TRAIL-induced apoptosis
• Regulation of sensitivity versus resistance towards TRAIL-induced apoptosis

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Walczak, H. (2007, October 1). TRAIL-induced apoptosis: from analysis of the death-inducing signalling complex (DISC) to clinical applicability [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 31, 2025, from https://doi.org/10.69645/SRJE9848.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Henning Walczak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.