• Evolution of the Apoptotic Pathway
• 52 min
  1. Apoptosis in C. elegans

  • Prof. Michael Hengartner
• 46 min
  2. Regulation of apoptosis: lessons from Drosophila and their implications for human health and disease

  • Prof. Hermann Steller
• The Apoptotic Pathway in Humans
• 29 min
  3. The death receptor signalling pathway

  • Dr. Richard Siegel
• 36 min
  4. Mitochondria and apoptosis

  • Prof. Stephen Tait
• Apoptosis Molecules
• 24 min
  5. The Bcl-2 family

  • Dr. David Huang
• 43 min
  6. Caspases

  • Prof. Yuri Lazebnik
• 37 min
  7. Natural caspase inhibitors

  • Prof. Guy Salvesen
• 44 min
  8. Mechanisms of apoptosis from structural biology

  • Prof. Yigong Shi
• 27 min
  9. TRAIL-induced apoptosis: from analysis of the death-inducing signalling complex (DISC) to clinical applicability

  • Dr. Henning Walczak
• Clearance of Apoptotic Cells
• 28 min
  10. Phagocytosis of apoptotic cells

  • Prof. Peter Henson
• Non-Apoptotic Cell Death Programs
• 34 min
  11. Autophagic cell death

  • Prof. Eric Baehrecke
• Apoptosis and Disease
• 64 min
  12. p53 and apoptosis

  • Prof. Moshe Oren
• 47 min
  13. The p53 family: function and molecular mechanisms

  • Prof. Gerry Melino
• 62 min
  14. Apoptosis in the immune system

  • Prof. Peter Krammer
• 68 min
  15. Apoptosis in the nervous system

  • Prof. Pierluigi Nicotera
• Clinical Application of Apoptosis Research
• 49 min
  16. Endothelial cell apoptosis

  • Prof. Richard Kolesnick
• 31 min
  17. Targeting apoptosis pathways in cancer therapy

  • Dr. Simone Fulda
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  18. Targeting apoptosis pathways in cancer therapy

  • Dr. Irene Ghobrial
• 20 min
  19. Apoptotic pathways in mammals

  • Prof. Douglas Green
• 46 min
  20. Lysosomal cell death pathways: new possibilities for cancer therapy

  • Prof. Marja Jaattela
• 57 min
  21. Degradation of apoptotic cells

  • Prof. Shigekazu Nagata
• 61 min
  22. Signaling during engulfment: the beginnings of a good meal

  • Prof. Kodi Ravichandran
• 29 min
  23. Apoptotic cell clearance deficiencies

  • Prof. Martin Herrmann
• 46 min
  24. Caspase inhibitors in drug discovery

  • Dr. Tom O'Brien
• 28 min
  25. Mitochondria in apoptosis

  • Prof. Jean-Claude Martinou

Printable Handouts

PDF

Navigable Slide Index

1. Introducation
2. The dual role of mitochondria in life and death
3. Mitochondria: the Pandora's box
4. The mitochondrial apoptogenic factors
5. How does Pandora's box open?
6. Two fundamental questions
7. Bcl-2 family
8. Three dimensional structure
9. A hydrophobic pocket interacts with BH3 domains
10. TM domain occupies Bax hydrophobic pocket
11. Two functional classes of BH3-only proteins
12. Bax under resting conditions
13. Bax during apoptosis
14. How antiapoptotic proteins protect cells
15. Conclusion 1
16. Two fundamental questions
17. The PTP cytochrome c release model (1)
18. The permeability transition pore
19. The PTP cytochrome c release model (2)
20. Opening the PTP raises questions
21. What about VDAC?
22. Bax channel model for cytochrome c release
23. Bcl-2 and bacterial toxins are structuraly similar
24. Bax pores
25. Bax/VDAC channel model for cytochrom c release
26. Lipidic pores/protein-lipid complex model
27. Structure of phospholipids
28. Bax lipidic pores
29. Summary
30. The role of mitochondrial fission in apoptosis
31. Bax-induced mitochondrial fragmentation
32. Fusion and fission machineries
33. Mitochondrial fission in apoptosis
34. A different view on mitochondria
35. Loss of OPA1 function and mitochondrial fission
36. Mitochondrial fission and cytochrome c release
37. Perspectives

Topics Covered

• Cell death
• Apoptosis
• Mitochondria
• Mitochondrial membrane permeabilization
• Bcl-2
• Bax
• Permeability transition pore
• Cytochrome c
• Mechanistic explanations
• Cancer
• Degenerative diseases

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on October 31, 2021

Financial Disclosures

• Prof. Jean-Claude Martinou has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.