Rules and filters and their impact on success in chemical biology and drug discovery

Published on April 2, 2014   78 min

Other Talks in the Series: Small Molecule Drug Discovery

0:00
Hello. My name is Chris Lipinski. And I'm currently a scientific adviser to Melior Discovery. Melior Discovery is a little start-up company that's located in Pennsylvania. The offices and vivarium are in Pennsylvania. I actually work out of my home office, in Waterford, Connecticut. And the title of today's talk is, Rules and Filters and Their Impact on Success in Chemical Biology and Drug Discovery.
0:32
The second slide is an outline of the topics I'd like to cover in this talk. It essentially consists of two parts. The first part, I'll be talking about academic targets and the translational gap. I'll talk about chemistry and nutrition, how it's getting worse with time. And reductionism, genomics, HTS, are they to blame? And in this first half, some comments about screening diverse compounds. And an important point is that screening diverse compounds really is the worst way to discover a drug. In the second part of the talk, I'll become a little bit more detailed, talking about what is a medicinal chemist? I'll try to get the point across that I firmly believe that medicinal chemistry is a pattern recognition discipline. I'll go on to some discussion of biology and chemistry networks analysis. And then I'll finish up with some comments about ligand efficiency and selectivity.
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Rules and filters and their impact on success in chemical biology and drug discovery

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