Stem and progenitor cells from peripheral blood

Published on March 5, 2014   45 min
0:00
Hello, my name is Shay Soker, and I'm a professor at the Wake Forest Institute for Regenerative Medicine. I'll be talking today about stem and progenitor cells from peripheral blood.
0:14
The bone marrow is, most likely, the source of stem and progenitor cells in peripheral blood. Hemangioblasts are the embryonic precursors of the hematopoietic stem cells, or HSCs, and they would give rise to the committed hematopoietic cells. Bone marrow mesenchymal cells, or MSCs, have multi-lineage differentiation potentials. Endothelial progenitor cells, or EPCs, are probably derived from hemangioblast precursors of hematopoietic stem cells, but they differentiate into endothelial cells, or ECs. My lecture will focus on EPCs and their role in neo-vascularization
0:58
As a definition, I want to highlight two processes. The first is angiogenesis- - the process of forming of new vessels from pre-existing blood vessels. The second one is vasculogenesis- - the assembly of capillaries from endothelial progenitor cells. And I will discuss during the lecture, the physiologic neo-vascularization and pathologic neo-vascularization.
1:27
The embryonic development of the vasculature, as I told you before- - it starts with the primary hepatoblasts that differentiates into angioblasts. These angioblasts will further go and differentiate into endothelial cells to form the primitive plexus, and under the induction of other angiogenic prospectus, which we'll be discussing later on, they form the mature vascular system. Once this vascular system is formed, it stays quiescent under another set of growth factors, one of which is angiopoietin-1, or ANG-1. Now, the process of angiogenesis and vasculogenesis also occurs during adult life but is mostly restricted to angiogenesis. Upon stimulation using growth factors such as angiopoietin-2 and VEGF, the endothelial cells are activated, and then they form new vessels. Recently- - and that's going to be the topic of this lecture- - it was shown that the immature hemangioblasts and angioblasts may also contribute to adult neo-vascularization.
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Stem and progenitor cells from peripheral blood

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