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1. Introduction
2. Different signals influence apoptosis
3. "Gas" and "Brake" model of apoptotic control
4. Reaper, Hid and Grim are required for apoptosis
5. Reaper, Hid and Grim are key killer genes
6. Genetic screen for cell death genes
7. Reaper family proteins
8. DIAP1 is the target for cell killing by RHGs
9. The N-terminus of Reaper, Hid and Grim
10. Reaper family proteins contain a conserved motif
11. RHG binding in Drosophila & mammals
12. Reaper mimetics can disrupt BIR caspase binding
13. IAP's and cancer
14. Ubiquitination and apoptosis
15. Expression of Reaper reduces half life of IAP
16. Reaper stimulates DIAP1 auto-ubiquitination
17. Dual role of Reaper
18. Diap-1 mediated ubiquitination
19. diap1 -/- cells don't survive
20. RING mutant cells undergo apoptosis
21. RING domain restricts pre-Droc protein levels
22. DIAP1 prevents inappropriate apoptosis
23. Cell proliferation mitogens in apoptotic cells
24. Cellular damage results in compensatory growth 1
25. Cellular damage results in compensatory growth 2
26. Active model of compensatory proliferation
27. Undead cells express wg and dpp
28. Wg signaling results in cell proliferation
29. Model for compensatory proliferation
30. Do mitochondria regulate caspases in Drosophila?
31. Caspase activation in spermatogenesis
32. Spermatid individualization in culture
33. Effector caspase-3-like drICE
34. Caspase inhibition blocks individualization
35. Screen of genes involved in caspase activation
36. Cyt c mutations
37. Sterility is rescued by Cyt c transgenes
38. Cyt-c-d & cyt-c-p rescue fertility
39. Cyt-C is required for effector caspase activation
40. Proteins required for normal apoptosis
41. Cyt-c-d promotes apoptosis
42. Apoptosome proteins
43. Cyt c is required for apoptosis
44. Generation of ARTS deficient mice
45. ARTS - summary
46. Generation of sept4-null mice
47. Why are Sept4-null mice sterile?
48. ARTS antagonizes IAPs
49. Sperm differentiation in Drosophila and mammals
50. ARTS, apoptosis and tumorigenesis
51. Acquired characteristics of cancer cells
52. Sept4-null mice develop lymphoma
53. "Gas" and "Brake" model - summary
54. Acknowledgements

Topics Covered

• Many different signals influence apoptosis
• "Gas" and "brake" model of apoptosis
• Reaper, Hid and Grim
• IAPs and cancer
• Use of Drosophila
• Ubiquitination and apoptosis
• diap1
• In proliferating tissues, damage induced cell death is compensated by extra growth of the neighboring cells
• Evidence for the "active model" of compensatory proliferation
• Regulation of caspase activation
• Cytochrome c is required for effector caspase activation in Drosophila spermatids
• Cyt-c-d and other apoptosome proteins are required for normal developmental apoptosis in the Drosophila retina
• Generation of Sept4-null mice
• Acquired characteristics of cancer cells

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Steller, H. (2007, October 1). Regulation of apoptosis: lessons from Drosophila and their implications for human health and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 24, 2025, from https://doi.org/10.69645/QDIF4648.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Hermann Steller has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.