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1. Introduction
2. Discovering HIV & AIDS genetic variants
3. Heterogeneity in the HIV epidemic
4. Natural history of HIV
5. Candidate gene association studies
6. Genotype-phenotype associations
7. Genetic models
8. CCR5 is a co-receptor for primary isolates of HIV
9. HIV cell entry
10. Consequence of Δ32 on the CCR5 protein
11. CCR5 Δ32 allele and genotype frequencies
12. CCR5 Δ32 homozygous individuals
13. CCR5 ∆32 effect on progression to AIDS
14. Trajectory of CD4 loss over time
15. Summary (CCR5 ∆32)
16. Bench to bedside translation
17. HIV-1 life cycle: chemokine-receptor nexus
18. HIV life cycle and points of restriction (1)
19. PPIA promoter SNP
20. HIV life cycle and points of restriction (2)
21. Effects of post-entry factors on progression
22. Summary (other factors)
23. Immune surveillance for viral pathogens
24. HLA gene classes
25. HLA-B27 protects against HIV progression
26. HLA candidate gene associations
27. Host & viruses evolving arms race
28. KIR regulate NK cell activity
29. KIR genes
30. Epistatic effect of KIR3DS1 & HLA-Bw4-80I
31. KIRxHLA interaction effect on AIDS-free survival
32. Genome wide association study (GWAS) era
33. GWAS success
34. Whole genome-wide association study
35. Quantile-quantile plot
36. Manhattan plot
37. GWAS publications
38. First HIV GWAS
39. Two SNPs determinants of viral set point
40. CD4<350 or ART initiation association with time
41. Increasing statistical power
42. Controller study data
43. Novel associations
44. Controlling HIV level vs. maintaining CD4 level
45. Long term non-progressors
46. Non-HLA and CCR5/2 associations from GWAS
47. HIV acquisition
48. HIV-related conditions
49. C22 and HIV-associated nephropathy
50. APOL1 risk alleles and sleeping sickness
51. Summary (GWAS)
52. Summary (final)
53. Future directions: a systems-based approach
54. Acknowledgements and disclaimers

Topics Covered

• Overview of candidate gene association studies of HIV and AIDS
• Key role for genetic variants involved in cell entry and host defenses
• Homozygous CCR5 32 basepair deletion prevents HIV Infection
• Acquired Immunity: HLA Class 1 proteins
• Key mediators of HIV progression
• Innate Protection: HLA and KIRS interactions in HIV disease
• Overview of Genome Wide Association Studies (GWAS)
• Overwhelming influence of HLA class I on HIV Progression and control of HIV viral load
• Non-HLA genetic associations with extreme phenotypes
• No new variants identified that prevent HIV infection
• Discovery of chromosome 22 associations with HIV-associated nephropathy
• Future studies
• Epigenetic, proteomic, functional studies
• Potential role of rare variants

Links

Categories:

• Genetics & Epigenetics
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on August 19, 2013

Financial Disclosures

• Dr. Cheryl A. Winkler has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.