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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Archibald E. Garrod
- What is a gene-environment interaction?
- For dichotomous outcomes
- Interaction effects can be described in three ways
- Quantitative traits
- Genetic effect for disease traits
- Removable interaction in risk ratio and log scale
- Removable interaction in quantitative data
- Examples of interactions
- Numerous examples of interaction
- Example of Eucalia plants
- Phenylketonuria
- Gene x environment interactions
- Genetic basis for weight gain
- Heritage family study
- Detecting gene x environment interactions
- Biological candidate gene approach
- Limitations of many existing studies of GxE
- Simply test GWAS main effects for interactions
- Type 2 diabetes
- Gene x lifestyle interaction on type 2 diabetes
- FTO gene
- FTO gene association with energy balance
- Difference in BMI between the different genotypes
- FTO gene x lifestyle interactions in diabetes
- Possible gene interactions
- Prospective meta-analysis
- If gene x environment interactions do not exist
- Heterogeneity associated with genotype
- Genotype-based recall randomized clinical trials
- Genetic population architecture
- Genotype-based recall trials
- Possible gene environment mechanisms (1)
- Possible gene environment mechanisms (2)
- Concluding remarks
Topics Covered
- Definition of gene-environment interaction
- Examples of interactions and rationale
- Why do we think gene x environment interactions might exist for complex, multifactorial traits?
- How might gene x environment interactions be detected?
- Limitations of many existing studies of gene x environment interactions
- Gene x lifestyle interaction on type 2 diabetes incidence
- Genotype-based recall randomized clinical trials
- What are the likely mechanisms underlying gene x environment interactions?
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Talk Citation
Franks, P. (2013, May 22). Gene-environment interactions in complex disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 2, 2024, from https://doi.org/10.69645/IUVV2946.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Paul Franks has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.