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- Introduction
- Conflict statement
- Outline
- The SEARCH study
- The latency period in the development of T1D
- Time to diabetes by number of Abs
- TrialNet and immune tolerance network
- Trial Net intervention studies
- Prevention and early diagnosis
- The diagnosis of T1D in children and youth
- Work up of diabetes type in youth
- Catastrophe at diagnosis - DKA
- The diagnosis
- Diabetes is hard to manage
- What is the course of type 1 diabetes
- DCCT, EDIC and rate of severe hypoglycemia
- The importance of glycemic control
- The insulin pump: more like a healthy pancreas
- Insulin pump therapy improves control
- CSII reduces incidents of severe hypoglycemia
- Continuous glucose monitoring
- Early control and beta-cell preservation
- STAR 3 study sites
- Study population
- A1C at 3, 6, 9, 12 months: all patients
- A1C at 3, 6, 9, 12 months: adults >= 19 years
- A1C at 3, 6, 9, 12 months: pediatrics 7–18 years
- A1C reduction is correlated with sensor use
- Cumulative severe hypoglycemia and DKA
- The benefit of early control
- Mean A1C values, SAP and crossover groups
- Prevalence of CVD risk factors in youth
- Helping the student with diabetes succeed
- The role of healthcare provider in treatment
- Evolution of a fully-automated delivery system
- How does LGS work?
- Low glucose suspend does what it is meant to do
- Subset of data mining
- Initial observations: children and adolescents
- Alert and suspend settings, all ages vs. pediatric
- Distribution of LGS events, all ages v pediatric (1)
- Distribution of LGS events, all ages v pediatric (2)
- LGS – glucose rate of change (ROC)
- Conclusions about LGS first automated feature
- Trial Net intervention studies (2)
- The closed loop system
- Overnight closed-loop glucose control
- The closed-loop in pediatric subjects
- Glucose values: home SCII vs. closed loop
- Closed-loop Insulin delivery – RCT
- Conclusions
Topics Covered
- The SEARCH study
- The latency period in the development of T1D
- Time to diabetes by number of Abs
- TrialNet and Immune Tolerance Network international consortia
- Prevention and early diagnosis
- The diagnosis of T1D in children and youth
- Work up of diabetes type in youth
- Catastrophe at diagnosis: DKA
- What is the course of type 1 diabetes
- DCCT, EDIC and rate of severe hypoglycemia
- The importance of glycemic control
- The insulin pump: more like a healthy pancreas
- CSII reduces incidents of severe hypoglycemia
- Continuous glucose monitoring
- Early control and beta-cell preservation
- STAR 3 study
- A1C reduction is correlated with sensor use
- Prevalence of CVD risk factors in youth
- The role of healthcare provider in treatment
- Evolution of a fully-automated delivery system
- How does LGS work?
- The closed-loop system
Links
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Therapeutic Areas:
Talk Citation
Kaufman, F. (2013, May 22). The treatment of type 1 diabetes in children and youth [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 22, 2022, from
https://hstalks.com/bs/2537/.
Publication History
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Published on May 22, 2013
Financial Disclosures
- Prof. Francine Kaufman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.