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1. Introduction
2. Pathophysiology of asthma - common wisdom
3. Talk outline
4. Airflow limitation/obstruction
5. Forced expiratory vital capacity maneuver (1)
6. Forced expiratory vital capacity maneuver (2)
7. Spirometry (1)
8. Spirometry (2)
9. FEV1
10. Uses of spirometry in asthma
11. The flow-volume loop (1)
12. The flow-volume loop (2)
13. The flow-volume loop (3)
14. Cross sectional variance for FEV1 and FVC
15. Spirometry is age, race and gender dependent
16. Spirometry (3)
17. The FEV1/FVC falls with age
18. Accelerated decline in lung function in asthma (1)
19. Accelerated decline in lung function in asthma (2)
20. Asthma severity and initiating treatment in youths
21. Levels of asthma control
22. The heterogeneous airways
23. What is a small airway ?
24. Resistance generation
25. Narrowing of parallel airways
26. Obstruction of parallel airways
27. Retrograde catheter
28. Retrograde catheter study
29. Peripheral airway resistance
30. Time of the day influence on peripheral resistance
31. Lung volumes
32. Hyperinflation defends the FEV1
33. Am chest tightness correlates with RV
34. Closing volume/capacity
35. Imaging modalities to evaluate small airways
36. MRI + hyperpolarized 3He (1)
37. Enhanced lung deposition with small particle size
38. Effect of particle size on FEV1
39. Reversibility
40. Spirometry (4)
41. Significant bronchodilator response
42. Bronchodilator responsiveness variability
43. Bronchodilator response flow volume loops
44. Patterns of responses
45. Isovolume shift
46. Best index of a bronchodilator effect (1)
47. Best index of a bronchodilator effect (2)
48. Best index of a bronchodilator effect (3)
49. Bronchodilator response is airway opening
50. MRI + hyperpolarized 3He (2)
51. Assumption: fall in FEV1 is due to "remodeling"
52. Mechanisms of airway obstruction
53. Airway remodeling: friend or foe?
54. Periodicity of airflow limitation
55. Asthmatic peak flow diary data
56. Airways hyper-responsiveness and PEF variability
57. Asthma: temporal periodicity
58. Forced oscillations test (FOT) (1)
59. Forced oscillations test (FOT) (2)
60. Resistance differences
61. Airways hyper-responsiveness (1)
62. Airways hyper-responsiveness (2)
63. Airway hyper-responsiveness correlations
64. Why perform an airways challenge test?
65. Bronchial provocation tests
66. Antigen-induced airway hyper-responsiveness
67. Exercise induced bronchospasm
68. Bronchoprovocation and severity
69. Inhibition of deep inspirations
70. Therapy guide through bronchoprovocation
71. Time courses of improvement in asthma
72. Summary (1)
73. Control of airway caliber and patency
74. Summary (2)
75. Heterogeneity of reversibility
76. Summary (3)
77. The signal is the noise
78. Summary (4)
79. Acknowledgements and dedication

Topics Covered

• Physiology of asthma, a syndrome defined by lung dysfunction
• Airflow limitation
• Small airways
• Reversibility of airflow limitation
• Periodicity and variability of airflow limitation
• Airways hyperresponsiveness

Links

Series:

• Advances in Asthma

Categories:

• Biochemistry
• Cell Biology
• Diseases, Disorders & Treatments

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on April 4, 2013

Financial Disclosures

• Prof. Charles G. Irvin, Grant/Research Support (Principal Investigator): NIH, American Lung Association.