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Printable Handouts
Navigable Slide Index
- Introduction
- Pathophysiology of asthma - common wisdom
- Talk outline
- Airflow limitation/obstruction
- Forced expiratory vital capacity maneuver (1)
- Forced expiratory vital capacity maneuver (2)
- Spirometry (1)
- Spirometry (2)
- FEV1
- Uses of spirometry in asthma
- The flow-volume loop (1)
- The flow-volume loop (2)
- The flow-volume loop (3)
- Cross sectional variance for FEV1 and FVC
- Spirometry is age, race and gender dependent
- Spirometry (3)
- The FEV1/FVC falls with age
- Accelerated decline in lung function in asthma (1)
- Accelerated decline in lung function in asthma (2)
- Asthma severity and initiating treatment in youths
- Levels of asthma control
- The heterogeneous airways
- What is a small airway ?
- Resistance generation
- Narrowing of parallel airways
- Obstruction of parallel airways
- Retrograde catheter
- Retrograde catheter study
- Peripheral airway resistance
- Time of the day influence on peripheral resistance
- Lung volumes
- Hyperinflation defends the FEV1
- Am chest tightness correlates with RV
- Closing volume/capacity
- Imaging modalities to evaluate small airways
- MRI + hyperpolarized 3He (1)
- Enhanced lung deposition with small particle size
- Effect of particle size on FEV1
- Reversibility
- Spirometry (4)
- Significant bronchodilator response
- Bronchodilator responsiveness variability
- Bronchodilator response flow volume loops
- Patterns of responses
- Isovolume shift
- Best index of a bronchodilator effect (1)
- Best index of a bronchodilator effect (2)
- Best index of a bronchodilator effect (3)
- Bronchodilator response is airway opening
- MRI + hyperpolarized 3He (2)
- Assumption: fall in FEV1 is due to "remodeling"
- Mechanisms of airway obstruction
- Airway remodeling: friend or foe?
- Periodicity of airflow limitation
- Asthmatic peak flow diary data
- Airways hyper-responsiveness and PEF variability
- Asthma: temporal periodicity
- Forced oscillations test (FOT) (1)
- Forced oscillations test (FOT) (2)
- Resistance differences
- Airways hyper-responsiveness (1)
- Airways hyper-responsiveness (2)
- Airway hyper-responsiveness correlations
- Why perform an airways challenge test?
- Bronchial provocation tests
- Antigen-induced airway hyper-responsiveness
- Exercise induced bronchospasm
- Bronchoprovocation and severity
- Inhibition of deep inspirations
- Therapy guide through bronchoprovocation
- Time courses of improvement in asthma
- Summary (1)
- Control of airway caliber and patency
- Summary (2)
- Heterogeneity of reversibility
- Summary (3)
- The signal is the noise
- Summary (4)
- Acknowledgements and dedication
Topics Covered
- Physiology of asthma, a syndrome defined by lung dysfunction
- Airflow limitation
- Small airways
- Reversibility of airflow limitation
- Periodicity and variability of airflow limitation
- Airways hyperresponsiveness
Links
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Therapeutic Areas:
Talk Citation
Irvin, C.G. (2013, April 4). Physiology of asthma and involvement of small airways [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 28, 2021, from https://hstalks.com/bs/2532/.Publication History
Financial Disclosures
- Prof. Charles G. Irvin, Grant/Research Support (Principal Investigator): NIH, American Lung Association.
Physiology of asthma and involvement of small airways
Published on April 4, 2013
70 min