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1. Introduction
2. The statistics of HIV-TB for 2010
3. Over 80% of HIV-TB in sub-Saharan Africa
4. Where we are and where we are going with HIV-TB
5. Historical context: 1970s - 1980s
6. Sharp increase in global TB in 1980s
7. SIV caused HIV
8. June 5, 1981, the AIDS epidemic officially began
9. HIV-AIDS by December 2010 (~30 years later)
10. Regional HIV and AIDS statistics and features
11. Clinical WHO staging and relation to CD4 count
12. The TB-HIV interaction
13. The tubercle bacillus
14. Reasons for increase in risk of active TB
15. Risk of TB in persons with M. tuberculosis
16. Risk of TB increases as CD4 count decreases
17. TB incidence rates in HIV-infected patients
18. Growth in TB incidence in Africa, 1980-2004
19. TB with HIV is highest in sub-Saharan Africa
20. Framework for TB control: 1994 "DOTS"
21. Targets for TB control
22. Global progress: fifteen years
23. Progress in Africa region
24. Effect of HIV on TB control
25. Programmatic effects
26. Notified TB cases in Malawi: 1985 - 2005
27. Malawi: TB and HIV interaction
28. TB increase lags behind HIV increase
29. HIV increases the number of women with TB
30. The women's TB ward in QECH, Malawi: 1995
31. Reasons for an increase in PTB suspects
32. Hot spots of TB transmission
33. Stigma
34. HIV weakens health care delivery
35. Survey in 40 Malawian hospitals: 1999
36. Patient management
37. Difficult diagnosis
38. Advancing HIV immune suppression
39. Smear-negative PTB
40. Normal CXR in PLHIV with TB
41. Slim disease
42. Diagnosis of TB in HIV-positive children
43. Deaths in new sm+ve PTB patients
44. Deaths in HIV-related TB
45. High rate of recurrent TB after treatment
46. Re-infection or re-activation?
47. HIV facilitates spread of drug-resistant TB
48. HIV derails achievement of targets
49. How to decrease the joint burden of HIV / TB?
50. Joint collaboration
51. The interim policy: Jan 2004
52. The WHO 12 points policy package
53. Mechanisms for collaboration
54. Program collaboration
55. Strong health systems
56. Listen to what co-infected patients want
57. Prevent TB in HIV-infected persons
58. The 3 "I"s: interdependent and complimentary
59. Key components
60. Care at an ART clinic in Malawi
61. TB symptom screen
62. Referring for TB investigations
63. Usual way of investigating for tuberculosis
64. Diagnosis of TB "Achilles Heel"
65. Isoniazid preventive therapy (IPT)
66. Guidelines for IPT
67. Progress with ICF and IPT
68. New ways of diagnosing TB in HIV settings (1)
69. New ways of diagnosing TB in HIV settings (2)
70. Empirical TB treatment for HIV infected patients
71. Think "outside the health sector"
72. WHO interim policy in hindsight
73. TB rates in HIV-infected patients in Cape Town
74. The current problem in sub-Saharan Africa
75. ART initiation for all PLHIV with low CD4 count
76. Early vs. standard ART in HIV-infected adults
77. A bolder approach is needed
78. Treating HIV in patients with TB
79. Stages from diagnosis to HIV-TB treatment
80. 2002: the rapid HIV test
81. Things to consider
82. Cotrimoxazole preventive therapy (CPT)
83. Antiretroviral therapy (ART)
84. WHO recommendations: ART guidelines in 2010
85. The CAMELIA trial
86. Recent published papers regarding ART
87. WHO statistics in 2010: 8.8 million TB cases
88. We need to do better
89. Do we have the money?
90. Bold vision
91. Thank you

Topics Covered

• Global HIV-Tuberculosis
• Historical context
• Interaction between the two pathogens (HIV and Mycobacterium tuberculosis)
• The Framework for Tuberculosis Control "DOTS"
• The effect of HIV on Tuberculosis control with respect to programme delivery and patient management
• The health sector response
• The WHO Interim Policy on decreasing the joint burden of HIV and tuberculosis
• Mechanisms for collaboration
• Preventing TB in HIV-infected persons
• Treating HIV in patients with TB
• Conclusion

Links

Series:

• Tuberculosis

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases
• Respiratory Diseases

Talk Citation

Harries, A.D. (2013, February 28). Impact of HIV on tuberculosis in the developing world and how to manage it [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 30, 2025, from https://doi.org/10.69645/TTGC3081.
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Publication History

• Published on February 28, 2013

Financial Disclosures

• Prof. Anthony D. Harries has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.