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1. Introduction
2. No financial disclosures to make
3. Exceptional longevity
4. Exceptional health span
5. Genetic basis of exceptional longevity
6. Rationale
7. Genome-wide association study
8. Genetic signatures of exceptional longevity
9. Genetic risk modeling
10. Longevity genes
11. Genetic model
12. The method's accuracy and specificity
13. Genetic risk profile
14. Highly predictive genetic risk profiles
15. Signatures (clusters of profiles)
16. Genetic dissection
17. Burden of disease alleles
18. Revised hypothesis
19. Drop APOE (rs2075650) from GRM
20. Conclusions - what centenarians tell us?
21. Acknowledgements

Topics Covered

• Genetic component of survival past 100
• Impact of 100s of genes
• Combinations of variations
• Number of signatures associated with survival to extreme old age

Links

Series:

• Biomarkers

Categories:

• Genetics & Epigenetics

Talk Citation

Perls, T. (2013, January 31). Building genetic and environmental marker models to predict exceptional survival [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/ISKS4096.
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Publication History

• Published on January 31, 2013

Financial Disclosures

• Prof. Thomas Perls has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.