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1. Introduction
2. Bacterial evasion of phagocyte killing
3. Aim of presentation
4. The macrophage
5. A central part of the immune system
6. The neutrophil - effective killer of bacteria
7. Phagocytosis - receptor-ligand interactions
8. Phagosome maturation and intracellular killing
9. Bacterial mechanisms to evade phagocytosis
10. The complement system
11. Expression of a polysaccharide capsule
12. Group B streptococcus (GBS)
13. Pathogenesis of neonatal GBS infections
14. Polysaccharide capsule - structure and function
15. Polysaccharide capsule: antiphagocytic properties
16. Streptococcus pyogenes
17. Schematic surface structure of S. pyogenes
18. M protein - an antiphagocytic surface protein (1)
19. M protein - an antiphagocytic surface protein (2)
20. M protein - an antiphagocytic surface protein (3)
21. Evasion of the complement system
22. Evasion of non-opsonic phagocytosis
23. Pattern recognition receptors (PRR)
24. Scavenger receptor A (SR-A)
25. Can the M protein mask the ligands for PRRs?
26. Evasion of SR-A mediated phagocytosis
27. Targeting of inhibitory receptors
28. Human Siglec-5
29. GBS beta protein binds Human Siglec-5 (1)
30. GBS beta protein binds Human Siglec-5 (2)
31. Type III secretion system (1)
32. Type III secretion system (2)
33. Yersinia T3SS-mediated phagocytosis resistance
34. Increased intracellular survival
35. M. tuberculosis and phagolysosomal maturation
36. L. monocytogenes - escaping the phagosome
37. Conclusions

Topics Covered

• Background on phagocytic cells
• The central role of the macrophage in the immune system
• The effectiveness of the neutrophil at killing bacteria
• Phagocytosis
• Receptor-ligand interactions
• Phagosome maturation and intracellular killing
• Different types of phagocytosis and phagocytic killing mechanisms
• Bacterial mechanisms to evade phagocytosis/phagocytic killing: Evasion of complement-mediated phagocytosis, Evasion of non-opsonic phagocytosis, Targeting of inhibitory receptors, Evasion via T3SS , Increased intracellular survival

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Diseases, Disorders & Treatments
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on January 31, 2013

Financial Disclosures

• Dr. Thomas Areschoug has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.