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Printable Handouts
Navigable Slide Index
- Introduction
- Bacterial evasion of phagocyte killing
- Aim of presentation
- The macrophage
- A central part of the immune system
- The neutrophil - effective killer of bacteria
- Phagocytosis - receptor-ligand interactions
- Phagosome maturation and intracellular killing
- Bacterial mechanisms to evade phagocytosis
- The complement system
- Expression of a polysaccharide capsule
- Group B streptococcus (GBS)
- Pathogenesis of neonatal GBS infections
- Polysaccharide capsule - structure and function
- Polysaccharide capsule: antiphagocytic properties
- Streptococcus pyogenes
- Schematic surface structure of S. pyogenes
- M protein - an antiphagocytic surface protein (1)
- M protein - an antiphagocytic surface protein (2)
- M protein - an antiphagocytic surface protein (3)
- Evasion of the complement system
- Evasion of non-opsonic phagocytosis
- Pattern recognition receptors (PRR)
- Scavenger receptor A (SR-A)
- Can the M protein mask the ligands for PRRs?
- Evasion of SR-A mediated phagocytosis
- Targeting of inhibitory receptors
- Human Siglec-5
- GBS beta protein binds Human Siglec-5 (1)
- GBS beta protein binds Human Siglec-5 (2)
- Type III secretion system (1)
- Type III secretion system (2)
- Yersinia T3SS-mediated phagocytosis resistance
- Increased intracellular survival
- M. tuberculosis and phagolysosomal maturation
- L. monocytogenes - escaping the phagosome
- Conclusions
Topics Covered
- Background on phagocytic cells
- The central role of the macrophage in the immune system
- The effectiveness of the neutrophil at killing bacteria
- Phagocytosis
- Receptor-ligand interactions
- Phagosome maturation and intracellular killing
- Different types of phagocytosis and phagocytic killing mechanisms
- Bacterial mechanisms to evade phagocytosis/phagocytic killing: Evasion of complement-mediated phagocytosis, Evasion of non-opsonic phagocytosis, Targeting of inhibitory receptors, Evasion via T3SS , Increased intracellular survival
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Talk Citation
Areschoug, T. (2013, January 31). How bacterial pathogens avoid phagocyte killing [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 22, 2021, from https://hstalks.com/bs/2485/.Publication History
Financial Disclosures
- Dr. Thomas Areschoug has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
How bacterial pathogens avoid phagocyte killing
Published on January 31, 2013
23 min