Macrophage phagocytosis

Swanson, Joel

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Introduction
Phagocytosis
Time-lapse video of a macrophage ingesting cells
Targets of macrophage phagocytosis
The importance of macrophage phagocytosis
Fc receptor-mediated phagocytosis
Actin cytoskeleton during phagocytosis
Receptors guide or trigger phagosome formation
Short & medium range signaling from Fc receptors
Essential phosphoinositides of phagocytosis
PI(3,4,5)P3 levels on phagocytic cup membranes
Fc-gamma receptors
Actin cytoskeleton moves in phagosome formation
Movements of the actin cytoskeleton
Rac signaling and phagocytosis (1)
Rac signaling and phagocytosis (2)
Rac1 activation during phagocytosis
Sources of membrane for phagosome formation
Patterns of activities in forming phagosomes
Coordination of phagosome formation
Target geometry affects phagocytosis
Coordination of signaling for phagocytosis
Receptors associated with phagocytosis
CR3 signaling for phagocytosis
Phagocytosis of apoptotic cells
Many routes of entry into cells
Ruffling & macropinocytosis in response to M-CSF
Bacteria engulfed in macropinosome-like vacuoles
Phagosomes change before fusing with lysosomes
Phagosomes acidify before & after fusion
Phagosomes mature by sequential interactions
Microbicidal chemistries in phagosomes
Phagocyte oxidase activity during phagocytosis
Manipulation by microbes
Summary
Acknowledgments
References

Topics Covered

The importance and targets of macrophage phagocytosis
Phagosome formation & maturation
Roles of receptors, actin cytoskeleton and phosphoinositides during phagocytosis
Target geometry effects on phagocytosis
Signaling for phagocytosis
Phagocytosis of apoptotic cells
Ruffling & macropinocytosis
Microbicidal chemistries in phagosomes
Manipulation by microbes

Links

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Macrophage Heterogeneity and Function

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Talk Citation

Swanson, J. (2013, January 30). Macrophage phagocytosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 26, 2021, from https://hstalks.com/bs/2482/.