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Printable Handouts
Navigable Slide Index
- Introduction
- Phagocytosis
- Time-lapse video of a macrophage ingesting cells
- Targets of macrophage phagocytosis
- The importance of macrophage phagocytosis
- Fc receptor-mediated phagocytosis
- Actin cytoskeleton during phagocytosis
- Receptors guide or trigger phagosome formation
- Short & medium range signaling from Fc receptors
- Essential phosphoinositides of phagocytosis
- PI(3,4,5)P3 levels on phagocytic cup membranes
- Fc-gamma receptors
- Actin cytoskeleton moves in phagosome formation
- Movements of the actin cytoskeleton
- Rac signaling and phagocytosis (1)
- Rac signaling and phagocytosis (2)
- Rac1 activation during phagocytosis
- Sources of membrane for phagosome formation
- Patterns of activities in forming phagosomes
- Coordination of phagosome formation
- Target geometry affects phagocytosis
- Coordination of signaling for phagocytosis
- Receptors associated with phagocytosis
- CR3 signaling for phagocytosis
- Phagocytosis of apoptotic cells
- Many routes of entry into cells
- Ruffling & macropinocytosis in response to M-CSF
- Bacteria engulfed in macropinosome-like vacuoles
- Phagosomes change before fusing with lysosomes
- Phagosomes acidify before & after fusion
- Phagosomes mature by sequential interactions
- Microbicidal chemistries in phagosomes
- Phagocyte oxidase activity during phagocytosis
- Manipulation by microbes
- Summary
- Acknowledgments
- References
Topics Covered
- The importance and targets of macrophage phagocytosis
- Phagosome formation & maturation
- Roles of receptors, actin cytoskeleton and phosphoinositides during phagocytosis
- Target geometry effects on phagocytosis
- Signaling for phagocytosis
- Phagocytosis of apoptotic cells
- Ruffling & macropinocytosis
- Microbicidal chemistries in phagosomes
- Manipulation by microbes
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Talk Citation
Swanson, J. (2013, January 30). Macrophage phagocytosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 23, 2021, from https://hstalks.com/bs/2482/.Publication History
Financial Disclosures
- Prof. Joel Swanson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Macrophage phagocytosis
Published on January 30, 2013
34 min