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1. Introduction
2. Phagocytosis
3. Time-lapse video of a macrophage ingesting cells
4. Targets of macrophage phagocytosis
5. The importance of macrophage phagocytosis
6. Fc receptor-mediated phagocytosis
7. Actin cytoskeleton during phagocytosis
8. Receptors guide or trigger phagosome formation
9. Short & medium range signaling from Fc receptors
10. Essential phosphoinositides of phagocytosis
11. PI(3,4,5)P3 levels on phagocytic cup membranes
12. Fc-gamma receptors
13. Actin cytoskeleton moves in phagosome formation
14. Movements of the actin cytoskeleton
15. Rac signaling and phagocytosis (1)
16. Rac signaling and phagocytosis (2)
17. Rac1 activation during phagocytosis
18. Sources of membrane for phagosome formation
19. Patterns of activities in forming phagosomes
20. Coordination of phagosome formation
21. Target geometry affects phagocytosis
22. Coordination of signaling for phagocytosis
23. Receptors associated with phagocytosis
24. CR3 signaling for phagocytosis
25. Phagocytosis of apoptotic cells
26. Many routes of entry into cells
27. Ruffling & macropinocytosis in response to M-CSF
28. Bacteria engulfed in macropinosome-like vacuoles
29. Phagosomes change before fusing with lysosomes
30. Phagosomes acidify before & after fusion
31. Phagosomes mature by sequential interactions
32. Microbicidal chemistries in phagosomes
33. Phagocyte oxidase activity during phagocytosis
34. Manipulation by microbes
35. Summary
36. Acknowledgments
37. References

Topics Covered

• The importance and targets of macrophage phagocytosis
• Phagosome formation & maturation
• Roles of receptors, actin cytoskeleton and phosphoinositides during phagocytosis
• Target geometry effects on phagocytosis
• Signaling for phagocytosis
• Phagocytosis of apoptotic cells
• Ruffling & macropinocytosis
• Microbicidal chemistries in phagosomes
• Manipulation by microbes

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on January 30, 2013

Financial Disclosures

• Prof. Joel Swanson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.