Macrophage phagocytosis

Swanson, Joel

We noted you are experiencing viewing problems

Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems.
No luck yet? More tips for troubleshooting viewing issues
Contact HST Support access@hstalks.com

Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
For additional help, please don't hesitate to contact HST support access@hstalks.com

We hope you have enjoyed this limited-length demo

Request free trial
Recommend to your librarian

Share
Share This Lecture
Messaging

Outlook

Gmail

Yahoo!

WhatsApp
Social

Facebook

Twitter

LinkedIn

VKontakte
Permalink
Replay Talk

This is a limited length demo talk; you may login or review methods of obtaining more access.

Slides
Topics
Links
Citation

Printable Handouts

PDF

Navigable Slide Index

Introduction
Phagocytosis
Time-lapse video of a macrophage ingesting cells
Targets of macrophage phagocytosis
The importance of macrophage phagocytosis
Fc receptor-mediated phagocytosis
Actin cytoskeleton during phagocytosis
Receptors guide or trigger phagosome formation
Short & medium range signaling from Fc receptors
Essential phosphoinositides of phagocytosis
PI(3,4,5)P3 levels on phagocytic cup membranes
Fc-gamma receptors
Actin cytoskeleton moves in phagosome formation
Movements of the actin cytoskeleton
Rac signaling and phagocytosis (1)
Rac signaling and phagocytosis (2)
Rac1 activation during phagocytosis
Sources of membrane for phagosome formation
Patterns of activities in forming phagosomes
Coordination of phagosome formation
Target geometry affects phagocytosis
Coordination of signaling for phagocytosis
Receptors associated with phagocytosis
CR3 signaling for phagocytosis
Phagocytosis of apoptotic cells
Many routes of entry into cells
Ruffling & macropinocytosis in response to M-CSF
Bacteria engulfed in macropinosome-like vacuoles
Phagosomes change before fusing with lysosomes
Phagosomes acidify before & after fusion
Phagosomes mature by sequential interactions
Microbicidal chemistries in phagosomes
Phagocyte oxidase activity during phagocytosis
Manipulation by microbes
Summary
Acknowledgments
References

Topics Covered

The importance and targets of macrophage phagocytosis
Phagosome formation & maturation
Roles of receptors, actin cytoskeleton and phosphoinositides during phagocytosis
Target geometry effects on phagocytosis
Signaling for phagocytosis
Phagocytosis of apoptotic cells
Ruffling & macropinocytosis
Microbicidal chemistries in phagosomes
Manipulation by microbes

Links

Series:

Macrophage Heterogeneity and Function

Categories:

Therapeutic Areas:

Talk Citation

Swanson, J. (2013, January 30). Macrophage phagocytosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 23, 2021, from https://hstalks.com/bs/2482/.