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My name is Keith Kelley, and I am a professor of Immunophysiology
at the University of Illinois in Urbana-Champaign
I have been actively involved in studying immunology
and brain communication signals for 35 years
I have served as editor-in-chief of the scientific journal
Brain, Behavior, and Immunity since 2003
The title of this lecture is The Physiology of Innate Immunity
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Most of the lectures in this series on cells of the innate immune system
are devoted to specific cells and receptor signaling pathways
and how myeloid cells interact with lymphoid cells
The objective of my lecture is complementary to this theme but different
Here I aim to highlight the concept that
innate immune cells are a very important component
of the physiology of the entire body
I will do this by discussing the role of mononuclear myeloid cells
in contributing to the discoveries and contributions
of immunophysiology to seven areas of health that are shown on this slide
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All of us know what it feels like to be sick
In the case of flu, influenza causes numerous symptoms
fever, headache, fatigue, muscle and joint aches, and sleepiness
but the brain is required for manifestation of many of these symptoms
have you ever thought about how an infection can lead to these kinds of symptoms?
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Cells of the innate immune system provide an immediate response
to infection and tissue injury.
Most infections make us sick, so the question is
how can cells of the innate immune system contribute to all these symptoms?
The generic answer is that the immune system helps to maintain health
by interacting in a coordinated fashion with many organ systems in the body.
Physiology is the study of function.
The immune system should be viewed as just another physiological system
like the cardiovascular, central nervous, renal, musculoskeletal,
and neuroendocrine system.
All these physiological systems work together to maintain homeostasis.
This word derives from Greek roots that mean similar and standing still.
Therefore homeostasis refers to the regulation of the internal environment of the body
in an attempt to maintain a stable constant condition such as body temperature
and blood volume.
