IL-17 cytokine family and receptors

Published on December 18, 2012   23 min

A selection of talks on Immunology

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Hi everyone. My name is Seon Hee Chang. I work with Dr. Chen Dong at the M.D. Anderson Cancer Center. Our laboratory has been studying the regulation and function of the IL-17 cytokine family and their receptors.
For the last 10 years, there has been a lot of progress in understanding what IL-17 does to human health and disease. Targeting IL-17 by blocking its cytokine or its receptor has been pursued by several different companies to treat various autoimmune diseases. Recently, targeting IL-17 has been very effective, especially in treating psoriasis.
In this presentation, we will review various aspects of this new class of cytokine. What are IL-17 family cytokines and how IL-17 family cytokines are produced? We will discuss their regulation and cellular sources. Once they are produced, what type of cell do they target and what type of molecules do they produce and what are the signaling mechanisms for IL-17 family cytokines? Overall, how do the IL-17 family cytokines impact health and disease, and what are the remaining questions to explore?
The founding member of the IL-17 family cytokine is IL-17A also known as IL-17 which was first cloned in 1993 and 1995. It is a secreted glycosylated protein with conserved cysteine residues. The receptor for IL-17A or IL-17 receptor A was first cloned in 1995, and this protein is a single-pass, ubiquitously expressed type one transmembrane protein. After IL-17A and receptor A were found, the homologous proteins were identified and it was named IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F and homologous protein for IL-17 receptor A were found and named as receptor B, receptor C, receptor D, and receptor E.