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Printable Handouts
Navigable Slide Index
- Introduction
- Glycans have various functions
- Talk outline
- N-Glycosylation occurs at RER, Golgi apparatus
- Glycosyltransferases involved branching
- Major glycosyltransferases and their functions
- Role of N-glycans in the cell surface receptors
- N-glycan essential for glucose transporter location
- Glucose transporter 2(Glut2)
- Impaired glucose transport in GnT-IVa deficiency
- Integrin-mediated signaling
- Aberrant N-glycosilation affects Integrin function
- The ErbB family and ligands
- ErbB-mediated signaling pathways
- Potential N-glycosylation sites of the ErbB family
- Regulation of ErbB dimerization by N-glycan
- Diminished PECAM-signaling, ST6Gal I deficiency
- Role of alpha2,6-sialic acid-PECAM interaction
- Implications of glycans in disease
- Chronic obstructive pulmonary disease (COPD)
- Pathogenesis of COPD
- Core fucose is a product catalyzed by Fut8
- Semi-lethality, growth retardation of Fut8 null mice
- TGF-beta receptor downregulated in Fut8-/- lung
- Enhanced degrading of ECM, lung emphysema
- Cigarette smoke decreased FUT8 activity
- Fut8 heterozygous KO mice and cigarette smoke
- Take home message
- Acknowledgements
- References
Topics Covered
- Review of cell surface glycoprotein receptors
- Glucose transporters 2
- Integrins
- Epidermal growth factor receptor
- Platelet Endothelial adhesion molecules
- Transforming growth factor beta receptor
- the common structure of these receptors
- Production of N-glycans
- N-glycans in disease: diabetes and COPD
Talk Citation
Taniguchi, N. (2012, November 27). Glycan regulation of receptor functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 14, 2024, from https://doi.org/10.69645/OIVA3239.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Naoyuki Taniguchi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.