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- General Strategies in Biomarker Research
-
1. The proteomic revolution
- Dr. Larry Gold
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2. Lipid biomarkers: lipidomics of the macrophage and plasma lipidomes
- Prof. Edward A. Dennis
- New Tools for Biomarker Research
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5. Development of glyco-biomarkers using glycoproteomics technologies
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6. Circulating nucleic acids as biomarkers in cancer patients
- Prof. Klaus Pantel
- Specific Disease Applications
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7. Biomarkers in breast cancer
- Prof. Joe Duffy
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8. Bacterial biomarkers
- Dr. Christiane Honisch
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9. Diabetes biomarkers
- Prof. Naveed Sattar
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10. Gene networks, brain networks: understanding schizophrenia
- Dr. Daniel Weinberger
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11. Biomarkers for Huntington's disease - promises and challenges
- Prof. Sarah Tabrizi
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12. Update on fluid biomarkers for neurodegenerative diseases
- Prof. Henrik Zetterberg
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13. Biomarkers in osteoarthritis
- Dr. Ali Mobasheri
- Biomarkers in Drug Discovery and Delivery
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14. Pharmacogenomics: emphasis on clinical drug development
- Dr. Amelia Warner
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15. Biomarkers in drug development: potential use and challenges
- Dr. Abdel-Bassett Halim
- Biomarkers in development, nutrition, and health
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18. Ethnic differences in nutrition
- Prof. Jose Ordovas
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19. Non-invasive prenatal diagnostics
- Prof. Y. M. Dennis Lo
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20. Epigenetic biomarkers in cancer
- Prof. Bob Brown
- Archived Lectures *These may not cover the latest advances in the field
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21. Biomarkers for Alzheimer's disease
- Prof. Henrik Zetterberg
Printable Handouts
Navigable Slide Index
- Introduction
- This presentation
- Bacterial biomarkers - overview
- Bacterial infections and biomarkers
- Robert Koch's postulates
- Identification of bacterial biomarkers
- Important factors for bacterial biomarkers
- Classification of bacterial biomarkers
- Bacterial biomarkers in diagnostic laboratories
- Groups of biomarkers
- The purpose of bacterial biomarkers
- Some taxonomic markers
- Resolution of some bacterial markers
- The history of epidemiological analysis
- Genomic markers
- Applications of nucleic acid markers
- Genomic markers - the benefit of PCR
- Proteomic markers
- Metabolic markers
- Biomarkers for microbial competition
- Technologies in clinical microbiology
- The principle of MALDI-TOF MS
- MALDI-TOF MS - one technology fits it all
- Future mass spectrometry developments
- Biomarkers and antibiotic resistance (1)
- Biomarkers and antibiotic resistance (2)
- Standard in vitro detection methods
- Nucleic acid based detection methods (1)
- Nucleic acid based detection methods (2)
- A complement of phenotypic analysis
- Applications of bacterial biomarkers
- Biomarkers in tuberculosis
- Potential clinical biomarkers in tuberculosis
- Tuberculosis outbreak monitoring
- Outbreak monitoring spoligotyping
- Bacterial biomarkers in Salmonella enterica
- Phenotypic method: serotyping
- Serotyping flowchart
- Biomarker requirements for molecular methods
- Alternative biomarkers and molecular methods
- Replacing serotyping by comparative sequencing
- Evolving biomarkers of the host
- Bacterial biomarkers in cystic fibrosis (CF)
- Properties of biomarkers in cystic fibrosis (CF)
- CF- host derived and bacterial biomarkers
- Conclusions
- Acknowledgements
- Thank you
- References (1)
- References (2)
- References (3)
- References (4)
- References (5)
- Abbreviations
Topics Covered
- Bacterial infections and biomarkers
- Bacterial biomarkers in today's diagnostic laboratories
- Identification, classification, purpose and groups of biomarkers
- Resolution and epidemiological analysis
- Genomic, proteomic and metabolic markers
- Mass spectrometry
- Antibiotic resistance
- Application examples of bacterial biomarkers
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Honisch, C. (2012, September 27). Bacterial biomarkers [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/CMGV6113.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Christiane Honisch, Stock Shareholder (Self-managed): Sequenom stock.
A selection of talks on Clinical Practice
Transcript
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0:00
Welcome to Henry Stewart presentation on bacterial biomarkers.
Thanks to the organizers of this series for
the opportunity to talk to you about the current state of
the art research and clinical applications of
biomarkers for bacterial detection, identification, and monitoring.
My name is Christiane Honisch.
I started my career in infectious disease biomarker research and
the development of novel methods for microbial detection and monitoring in 1999,
with a PhD in Molecular Biology and Microbiology from the Technical University,
Carolo-Wilhelmina zu Braunschweig in Germany.
My research was focused on the discovery of genomic and
proteomic markers for the detection of pathogenic mycobacteria,
mainly mycobacterium tuberculosis; the infectious agent for tuberculosis.
Continued interest in Nucleic Acids Research and Novel
technologies led to the past 11 years in industry
developing mass spectrometry applications for the detection and
monitoring of nucleic acid-based bacterial and viral biomarkers.
Public health institutions worldwide like
the Health Protection Agency in London in the UK,
and the Center of Disease Control and Prevention in Atlanta,
Georgia in the US embrace this Genome technology.
My current research interests at the University of California,
San Diego continues to be focused on microbial biomarkers and mass spectrometry,
now in microbial communities.
1:33
The following presentation will provide a general overview of
bacterial biomarkers especially of infectious disease agents combined
with an overview on developments of technology for example
mass spectrometry for the detection and monitoring of microorganisms.