Lipid biomarkers: lipidomics of the macrophage and plasma lipidomes

Dennis, Edward A.

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Navigable Slide Index

Introduction
Overview
LIPID MAPS
LIPID MAPS cores and bridges
CLASS
Kdo2-Lipid A
Macrophage lipid metabolism
Sterol biosynthesis pathway
Lipidomics components
www.lipidmaps.org
PLA2 function in arachidonic acid release
Eicosanoid signaling pathways in macrophage
Basic macrophage experimental scheme
Cellular eicosanoid metabolism (1)
Cellular eicosanoid metabolism (2)
KLA treatment in RAW macrophage
Fluxomics model for KLA treatment
Cellular eicosanoid metabolism (3)
Cellular eicosanoid metabolism (4)
Macrophage phenotypes
Eicosanoid changes by phenotype
COX-2 metabolites and transcripts
PGE2/PGD2 vs. PGES/PGDS transcripts
Proportionality of eicosanoids and transcripts
Directed proteomics on enzymes
Protein abundance after KLA stimulation
Eicosanoid genes to proteins to metabolites
Human plasma lipidomics
Human plasma metabolites
Human plasma lipid categories
Prostaglandins in the human plasma
Sterols in the human plasma
Human plasma lipid diversity
Plasma lipids in the metabolic syndrome
Acknowledgments
The LIPID MAPS consortium
Concluding remarks

Topics Covered

The LIPID MAPS initiative
Relating LIPID MAPS to genomics, proteomics and metabolomics
Lipidomics analysis
Eicosanoid metabolism in macrophages
Lipidomics analysis of human plasma

Links

Series:

Biomarkers

Categories:

Therapeutic Areas:

Immunology & Inflammation

Talk Citation

Dennis, E.A. (2012, September 27). Lipid biomarkers: lipidomics of the macrophage and plasma lipidomes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/GJIM9382.
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