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1. Introduction
2. Overview
3. Spinal cord injury (1)
4. Causes of spinal cord injury
5. Intraspinal bleeding and inflammation
6. Platelets and SCI: hemostasis and inflammation
7. Inflammatory signaling and cellular response
8. Inflammatory signaling: chemokines and cytokines
9. Neurons participate in inflammation onset
10. Summary to this point
11. Spinal cord injury (2)
12. Suppressing or enhancing inflammation
13. Inflammation: a historical definition
14. Inflammation
15. Injured tissue regeneration throughout evolution
16. What inflammation can be associated with
17. Macrophages co-localize with axons post SCI
18. Implications of inflammation after SCI
19. Inhibiting recruitment of WBCs is neuroprotective
20. Neutrophils and spinal cord injury
21. Macrophages and spinal cord injury
22. Macrophages dominate the site of SCI
23. Macrophages have injurious and reparative effects
24. Defining injurious or reparative macrophages
25. Macrophage diversity in the injured spinal cord
26. Molecular signature for intraspinal macrophages
27. SCI triggers a robust, sustained M1 response
28. M1 macrophages are toxic to cortical neurons
29. M1 and M2 macrophages: sprouting vs. elongation
30. Macrophage phenotype & function after SCI (1)
31. Macrophage phenotype & function after SCI (2)
32. Lymphocytes and spinal cord injury
33. Immune-mediated CNS injury or repair? (1)
34. Immune-mediated CNS injury or repair? (2)
35. Lymphocytes and spinal cord injury - references
36. Spinal cord injury and T cells
37. Impaired functional recovery in MBP TCR mice
38. Secondary injury exacerbated in MBP TCR mice
39. Rostro-caudal axon loss and demyelination
40. SCI activates B cells in spleen and bone marrow
41. Absence of B cells improves recovery after SCI
42. The CNS is "hard-wired" into the immune system
43. Collaborators

Topics Covered

• The conflicting effects of Inflammation in the injured spinal cord
• Progression of intraspinal bleeding
• The cellular and molecular components of acute and chronic inflammation
• The injurious and reparative effects on neurons and glia

Links

Series:

• Neurotrauma

Categories:

• Clinical Practice
• Immunology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on September 13, 2012

Financial Disclosures

• Prof. Phillip Popovich has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.