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Navigable Slide Index

1. Introduction
2. Regenerative medicine - definition
3. In vitro 3d constructs
4. TERM targets
5. Research stages - cells
6. Cell sources
7. Somatic stem cells
8. Embryonic stem cells
9. TERM stem cell sources
10. Challenge 1 - how to differentiate stem cells
11. Medium supplementation
12. Differentiation of adult stem cells
13. Challenge 2 - key components of medium
14. Medium composition for pneumocyte differentiation
15. Increased endoderm differentiation
16. Challenge 3 - other methods
17. Cell extracts
18. Normal cell behaviour
19. Challenge 4 - microenvironment
20. Microenvironment references
21. Microenvironment and differentiation
22. Challenge 5 - genetic modification
23. Gene modulation and differentiation
24. Research stages - materials
25. Materials for regenerative medicine
26. Materials - recent results
27. Research stages - scale up
28. Challenge 6 - how to produce enough cells
29. Bioreactors
30. Bioprocess engineering
31. Research stages - per-clinical tests
32. Challenge 7 - does it work in vivo
33. Animal models - for and against
34. Cardiac experiments
35. Challenge 8 - applicable to humans
36. Clinical trials
37. Cardiac clinical trials
38. Immunocompatibility
39. Nucler transfer and human cloning
40. Novalung
41. Novalung - mechanism of action
42. Conclusions

Topics Covered

• Regenerative medicine aims to repair, regenerate or replace damaged tissues and organs
• Selection of appropriate cell sources
• Plasticity
• Differentiation of stem cells towards target phenotypes
• Medium supplementation
• Exposure to cell extracts
• Direct or indirect co-culture with other cells/tissues
• Genetic modification
• Scaffolds
• Bioprocessing systems
• Pre-clinical testing of novel stem cell-based therapies in animal models of disease
• Clinical trials
• Treatment of ischaemic heart failure with autologous bone marrow stem cells

Links

Series:

• Stem Cells and Regenerative Medicine

Categories:

• Cell Biology

Talk Citation

Polak, J. and Bishop, A. (2007, October 1). Stem cells and regenerative medicine [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2023, from https://hstalks.com/bs/238/.
Export Citation (RIS)

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Dame Julia Polak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Anne Bishop has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.