Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Microglia: a short definition
3. Microglia: resident innate immune cells of CNS
4. Discovery and detection
5. Discovery, detection / functional interpretation (1)
6. Discovery, detection / functional interpretation (2)
7. Approaches to the study of microglia
8. Manipulating and monitoring microglial activities
9. Developmental origin and functions
10. Microglia as macrophage-like cells
11. Origin and lineage
12. Developmental contributions of malfunction (1)
13. Developmental contributions of malfunction (2)
14. Developmental contributions of malfunction (3)
15. The concept of resting microglia
16. Resting or active: dormant or functional
17. Tissue surveillance and synaptic nursing
18. Immunologically silent disposal of myelin
19. The concept of microglial activation
20. Immediate response to homeostatic disturbance
21. The concept of detrimental microglia
22. Microglial activation simply follows a stereotype
23. Microglial activation in CNS pathologies
24. Harmful microglial engagement is recognized
25. Activation signals and response diversity
26. Microglia as active sensors
27. Activity-controlling factors (1)
28. Activity-controlling factors (2)
29. Control via ON and OFF signals
30. Microglial response versatility
31. Macrophages and microglia
32. Signals and response modifiers
33. Elements of the microglial response repertoire (1)
34. Elements of the microglial response repertoire (2)
35. Response dynamics
36. Microglia activation: not a monophasic response
37. Microglia activation: deescalation / termination
38. Contributions in and to CNS pathologies
39. Phenotypes associated with phagocytosis
40. Effects associated with phagocytosis
41. Microglial neuropathology in Alzheimer's disease
42. Microglia in neurodegenerative diseases
43. A uniform population throughout the CNS or not?
44. Conclusion and outlook
45. Questions regarding roles in health and disease
46. Thank you

Topics Covered

• Physiology and pathophysiology of microglia
• Microglia
• resident innate immune cells of the CNS
• Approaches to the study of microglia
• Developmental origin and functions
• Developmental contributions and consequences of malfunction
• The concept of 'resting' microglia
• functions in the healthy adult CNS
• Tissue surveillance and synaptic nursing as house-keeping duties
• The concept of microglial 'activation'
• transformation to distinct activity states
• The concept of detrimental microglia
• Activation signals and response diversity
• Macrophages and microglia: diversity in response behaviour
• Elements of the microglial response repertoire
• Response dynamics
• Microglial phenotypes associated with phagocytosis
• Contributions of microglia in neurodegenerative diseases

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on July 15, 2012

Financial Disclosures

• Prof. Dr. Uwe-Karsten Hanisch has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.