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• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Prof. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Biology of myeloid cells (1)
3. Biology of myeloid cells (2)
4. Biology of myeloid cells (3)
5. Sites of hematopoiesis in the mouse embryo
6. CX3CR1-GFP macrophages
7. Macrophages in the developing embryo
8. Myb-/- lack HSC and definitive erythropoiesis
9. PU.1-dependent YS-macrophages
10. Fetal liver macrophages - MYB-deficient mice
11. Fetal spleen macrophages - MYB-deficient mice
12. Fetal brain macrophages - MYB-deficient mice
13. Fetal limbs macrophages - MYB-deficient mice
14. F4/80bright macrophages development (1)
15. F4/80bright macrophages development (2)
16. Conclusion (1)
17. Genome wide gene expression arrays
18. Supervised clustering: macrophages signatures
19. Cellular identity of F4/80bright macrophages
20. Fate-mapping analysis
21. Conclusion (2)
22. More fate-mapping of YS macrophages
23. Do YS macrophages survive in developing embryo?
24. E10.5 YS-derived macrophages survive
25. Limb graft
26. Fate-mapping analysis: a critical experiment
27. CSF1R-expressing E8.5 YS-precursors
28. Conclusions (3)
29. Conditional deletion of Myb in adult MxCre
30. Conditional deletion of Myb: results
31. Conditional deletion of Myb after 3 months
32. Conditional deletion of Myb induces loss of HSCs
33. Microglia development
34. Conclusions (4)
35. Myeloid cell development in the mouse
36. Biology of myeloid cells (4)
37. In situ proliferation of adult kidney macrophages
38. Langerhans cells proliferate in the epidermis
39. Langerhans cells in human
40. Langerhans cells differentiation in mice
41. During inflammation epidermal LC proliferate in situ
42. Epidermal LC proliferate in situ
43. LC proliferation control
44. Two myeloid lineages and their genetic regulation
45. Conclusions (5) and perspectives
46. Collaborators

Topics Covered

• Definition of monocytes, macrophages and dendritic cells
• Role of these cells in controlling innate inflammatory response and memory immune responses
• Involvement of the innate immune system in the pathophysiology of infectious and inflammatory diseases
• Development of different types of immune cells from different precursors
• The transcription factors and growth factors required to differentiate precursor cells into specific immune cells

Links

Series:

• Cells of the Innate Immune System

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 11, 2012

Financial Disclosures

• Prof. Frederick A. Geissmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.