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1. Introduction
2. Biology of myeloid cells (1)
3. Biology of myeloid cells (2)
4. Biology of myeloid cells (3)
5. Sites of hematopoiesis in the mouse embryo
6. CX3CR1-GFP macrophages
7. Macrophages in the developing embryo
8. Myb-/- lack HSC and definitive erythropoiesis
9. PU.1-dependent YS-macrophages
10. Fetal liver macrophages - MYB-deficient mice
11. Fetal spleen macrophages - MYB-deficient mice
12. Fetal brain macrophages - MYB-deficient mice
13. Fetal limbs macrophages - MYB-deficient mice
14. F4/80bright macrophages development (1)
15. F4/80bright macrophages development (2)
16. Conclusion (1)
17. Genome wide gene expression arrays
18. Supervised clustering: macrophages signatures
19. Cellular identity of F4/80bright macrophages
20. Fate-mapping analysis
21. Conclusion (2)
22. More fate-mapping of YS macrophages
23. Do YS macrophages survive in developing embryo?
24. E10.5 YS-derived macrophages survive
25. Limb graft
26. Fate-mapping analysis: a critical experiment
27. CSF1R-expressing E8.5 YS-precursors
28. Conclusions (3)
29. Conditional deletion of Myb in adult MxCre
30. Conditional deletion of Myb: results
31. Conditional deletion of Myb after 3 months
32. Conditional deletion of Myb induces loss of HSCs
33. Microglia development
34. Conclusions (4)
35. Myeloid cell development in the mouse
36. Biology of myeloid cells (4)
37. In situ proliferation of adult kidney macrophages
38. Langerhans cells proliferate in the epidermis
39. Langerhans cells in human
40. Langerhans cells differentiation in mice
41. During inflammation epidermal LC proliferate in situ
42. Epidermal LC proliferate in situ
43. LC proliferation control
44. Two myeloid lineages and their genetic regulation
45. Conclusions (5) and perspectives
46. Collaborators

Topics Covered

• Definition of monocytes, macrophages and dendritic cells
• Role of these cells in controlling innate inflammatory response and memory immune responses
• Involvement of the innate immune system in the pathophysiology of infectious and inflammatory diseases
• Development of different types of immune cells from different precursors
• The transcription factors and growth factors required to differentiate precursor cells into specific immune cells

Links

Series:

• Cells of the Innate Immune System

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 11, 2012

Financial Disclosures

• Prof. Frederick A. Geissmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.