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1. Introduction
2. Outline
3. MR structure and function
4. Domains and binding properties of MR
5. MR is an endocytic receptor
6. MR is a receptor for collagen
7. The MR family
8. MR expression
9. Regulation of MR expression in macrophages
10. MR conformation
11. MR conformation - bended conformation
12. MR-glycosylation
13. MR binding properties and glycosylation
14. MR and phagocytosis
15. MR and cellular activation
16. MR is shed
17. Fungi up-regulate MR shedding
18. Beta-glucan enhances MR shedding
19. Selected expression of CR-ligands
20. The "sMR-mediated delivery pathway"
21. Data in support of sMR-mediated Ag transport
22. Current hypothesis
23. CR-ligands in rat spleen
24. CR-ligands in human spleen
25. Structure and function: conclusions
26. MR and antigen presentation
27. MR and self-recognition
28. MR and antigen presentation to T cells
29. MR expression in secondary lymphoid organs
30. MR expression in lymph nodes
31. MR in CD11c high DC
32. MR ligands do not target T cell areas
33. MR expression is highly regulated
34. Targeting of anti-MR and LPS
35. MR ligands elicit enhanced humoral responses
36. MR ligands in peripheral tissues
37. MR and antigen presentation to T cells
38. MR and cross-presentation
39. MR and disease
40. Two MR-deficient strains
41. MR and host defence
42. MR and allergy
43. MR contributes to allergen uptake
44. MR deficiency reduces Th2 polarisation
45. IDO as the potential effector molecule
46. Increased IDO activity in MR-deficient DC
47. Inhibiting IDO restores Th2 polarisation
48. Mimicking IDO reduces Th2 polarisation
49. Inhibition of IDO - recap
50. MR deficiency reverse effect
51. IDO metabolite treatment
52. MR contributes to Fel d 1 allergenicity in vivo
53. MR variants and asthma susceptibility
54. MR and allergy: conclusions
55. MR as a promoter of Th2 polarisation
56. MR and cellular responses in LN draining site
57. MR and schistosomiasis: conclusions
58. MR and glomerulonephritis (NTN model)
59. Immuno-complexes deposition in kidneys
60. MR deficiency protects from renal injury
61. Interplay between MR and Fc receptors
62. MR promotes FcR-function
63. MR deficiency and mesangial cell proliferation
64. MR-deficient cells - less pro-inflammation
65. MR in murine NTN: conclusions
66. MR and cancer
67. MR is expressed in tumours
68. MR promotes anti-inflammatory response
69. MR promotes tumour metastasis
70. miR-511-3p modulates genetic programs
71. Regulation of cellular activation
72. Issues raised by the existence of miR-511-3p
73. MR and cancer: conclusions
74. Summary
75. Acknowledgements
76. Acknowledgements - research funding
77. Thank you for listening
78. References (1)
79. References (2)
80. References (3)
81. References (4)
82. References (5)

Topics Covered

• The mannose receptor (MR)
• Structure and function
• Domains and binding properties of MR
• The MR family
• MR expression
• MR as an endocytic receptor
• MR conformation and glycosylation
• MR and phagocytosis
• MR and cellular activation
• MR shedding
• Ligands for the cysteine-rich domain of MR
• MR and antigen presentation
• MR and self-recognition
• MR and activation of T cells
• MR and disease
• Role of MR in host defence
• MR and allergy
• MR and glomerulonephritis
• MR and cancer

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 11, 2012

Financial Disclosures

• Dr. Luisa Martinez-Pomares has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.