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• 68 min
  1. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation

  • Prof. Emeritus Siamon Gordon
• 25 min
  2. Biosimilars: when value meets cost

  • Prof. Fernando de Mora
• 25 min
  3. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
• 39 min
  4. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  5. Fetal macrophages

  • Prof. Paul Martin
• 44 min
  6. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  7. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  8. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  9. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  10. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  11. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  12. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  13. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  14. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  15. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  16. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  17. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

  • Prof. Ricardo Gazzinelli
• 34 min
  18. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
  19. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  20. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  21. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  22. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  23. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  24. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  25. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  26. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  27. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  28. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  29. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Regulated immune responses
3. Membrane protein interactions (1)
4. Paired leukocyte receptors
5. The Ly49 story (1)
6. The Ly49 story (2)
7. Summary: paired receptors
8. The SIRP family and their ligands
9. Specificity of SIRPalpha binding to CD47 (1)
10. Specificity of SIRPalpha binding to CD47 (2)
11. Specificity of SIRPalpha binding to CD47 (3)
12. Failure of SIRP betas to bind CD47
13. Mutating the His100 to Asp restores activity
14. Why the special binding face?
15. Driving force for paired receptor evolution
16. The counterbalance theory for paired receptors
17. What do the activating receptors bind?
18. Pathogen binding to activating receptors
19. Role of polymorphisms in paired receptors
20. The polymorphisms in SIRPalpha domain 1
21. SIRPalpha domain 1 is highly polymorphic
22. Why is SIRPalpha domain 1 so polymorphic?
23. What about other paired receptors?
24. Polymorphisms in LILRB1
25. Driving force for paired receptor evolution (1)
26. How is SIRPalpha organised at the cell surface?
27. SIRPalpha: a protein with 3 IgSF domains
28. SIRPalpha-CD47 topology of interaction
29. Membrane protein interactions (2)
30. Driving force for paired receptor evolution (2)
31. SIRPalpha moves to immunological synapse
32. Synapses prevent unwanted receptors targeting
33. Summary I
34. CD200R is another macrophage paired receptor
35. CD200-CD200 receptor interaction
36. Models for viral homologues of CD200
37. Some viral homologues of CD200 bind CD200R
38. Pathogen product targeting inhibitory CD200R
39. CD200 is a target for leukaemia
40. Inhibitory receptors as cancer therapy targets
41. Allergic diseases and asthma
42. Paired receptors and pathogen environment
43. Summary II
44. Acknowledgements

Topics Covered

• Immunoregulation and cell surface receptors
• Paired receptors
• Inhibitory
• Activating
• Myeloid cells
• X-ray crystallography
• Protein structure Ig superfamily domains
• Evolution Pathogen pressure
• Host environment interactions

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 8, 2012
• Reviewed on October 12, 2021

Financial Disclosures

• Prof. Neil Barclay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.