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1. Introduction
2. Regulated immune responses
3. Membrane protein interactions (1)
4. Paired leukocyte receptors
5. The Ly49 story (1)
6. The Ly49 story (2)
7. Summary: paired receptors
8. The SIRP family and their ligands
9. Specificity of SIRPalpha binding to CD47 (1)
10. Specificity of SIRPalpha binding to CD47 (2)
11. Specificity of SIRPalpha binding to CD47 (3)
12. Failure of SIRP betas to bind CD47
13. Mutating the His100 to Asp restores activity
14. Why the special binding face?
15. Driving force for paired receptor evolution
16. The counterbalance theory for paired receptors
17. What do the activating receptors bind?
18. Pathogen binding to activating receptors
19. Role of polymorphisms in paired receptors
20. The polymorphisms in SIRPalpha domain 1
21. SIRPalpha domain 1 is highly polymorphic
22. Why is SIRPalpha domain 1 so polymorphic?
23. What about other paired receptors?
24. Polymorphisms in LILRB1
25. Driving force for paired receptor evolution (1)
26. How is SIRPalpha organised at the cell surface?
27. SIRPalpha: a protein with 3 IgSF domains
28. SIRPalpha-CD47 topology of interaction
29. Membrane protein interactions (2)
30. Driving force for paired receptor evolution (2)
31. SIRPalpha moves to immunological synapse
32. Synapses prevent unwanted receptors targeting
33. Summary I
34. CD200R is another macrophage paired receptor
35. CD200-CD200 receptor interaction
36. Models for viral homologues of CD200
37. Some viral homologues of CD200 bind CD200R
38. Pathogen product targeting inhibitory CD200R
39. CD200 is a target for leukaemia
40. Inhibitory receptors as cancer therapy targets
41. Allergic diseases and asthma
42. Paired receptors and pathogen environment
43. Summary II
44. Acknowledgements

Topics Covered

• Immunoregulation and cell surface receptors
• Paired receptors
• Inhibitory
• Activating
• Myeloid cells
• X-ray crystallography
• Protein structure Ig superfamily domains
• Evolution Pathogen pressure
• Host environment interactions

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 8, 2012
• Reviewed on October 12, 2021

Financial Disclosures

• Prof. Neil Barclay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.