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  1. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
• 39 min
  2. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  3. Fetal macrophages

  • Prof. Paul Martin
• 44 min
  4. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  5. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  6. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  7. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  8. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  9. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  10. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  11. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  12. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  13. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  14. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

  • Prof. Ricardo Gazzinelli
• 34 min
  16. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
  17. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  18. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  19. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  20. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  21. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  22. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  23. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  24. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  25. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  26. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  27. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Recognising an invading organism
3. Recognising PAMPS
4. Research in flies
5. TLRs
6. TLR sensing pathogens
7. C-type lectin domain (CTLD)
8. CTLD groups
9. CTLD specific groups
10. MBL
11. MBL functions
12. MBL attack
13. MBL: intracellular signalling
14. Is MBL important?
15. Surfactant proteins
16. Surfactant proteins: functions
17. Triggering inhibitory intracellular signals
18. Are surfactant proteins important?
19. The membrane bound mannose receptor
20. The mannose receptor (MR) structure
21. The mannose receptor (MR) recognition
22. The role of the mannose receptor
23. Is the mannose receptor important?
24. DC-SIGN
25. DC-SIGN structure and recognition
26. Mannose-specific DC-SIGN signalling
27. Fucose-specific DC-SIGN signalling
28. Is DC-SIGN important?
29. Dectin-1
30. Dectin-1 structure
31. Dectin-1 crystal structure
32. Dectin-1 recognition
33. Particle uptake in Dectin-1 transfected cells
34. Innate responses mediated by Dectin-1
35. Dectin-1 recognises live fungal pathogens
36. Dectin-1 non-redundant role in antifungal immunity
37. Role of Dectin-1 in anti-fungal immunity: mouse
38. Human Dectin-1 polymorphism
39. Human Dectin-1 deficiency
40. Role of Dectin-1 in anti-fungal immunity: human
41. Role of Dectin-1 in adaptive immunity
42. Dectin-1 mediated intracellular signalling
43. Syk kinase
44. Dectin-1 triggers Raf-1 pathway
45. Dectin-1 signalling
46. Dectin-1 signalling for cytokine production
47. Collaborative signalling for cytokine production
48. Dectin-1 and TLR-2 are required for TNF induction
49. Chromoblastomycosis and Fonsecaea pedrosoi
50. Co-stimulation in vitro
51. Reason for chronic infection
52. Restoring inflammatory response
53. Repression of other cytokines
54. Co-stimulation affects type of adaptive response
55. Dectin-1 similarity to TLR
56. Dectin-2 and Mincle
57. Dectin-2
58. Is Dectin-2 important?
59. Mincle
60. Dectin-1, Dectin-2 and Mincle similarity to TLR
61. Pathogens recognised by Dectin-2/Mincle
62. Th17 responses and fungal infections
63. Summary
64. Acknowledgements

Topics Covered

• Role of pattern recognition receptors in extracellular pathogen recognition
• TLR and CLR
• Soluble CLRs and opsonisation
• MBL, SPA, SPD
• Membrane CLRs and signal transduction
• Mannose Receptor
• DC-SIGN
• Dectin-1
• Dectin-2
• MINCLE
• Innate and adaptive immune responses

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 8, 2012

Financial Disclosures

• Prof. Gordon Brown is supported by Wellcome Trust, MRC Centre for Medical Mycology and NIHR Exeter Biomedical Research Centre.