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1. Mononuclear phagocytes - origins, fates and functions
- Prof. Steffen Jung
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2. Transcription factors in macrophage differentiation
- Dr. Michael Sieweke
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3. Fetal macrophages
- Prof. Paul Martin
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4. The alveolar macrophage
- Dr. Ronald G. Crystal
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5. Airway macrophages in health and disease
- Prof. Tracy Hussell
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6. Intestinal macrophages - heterogeneity, origins and functions
- Prof. Allan Mowat
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7. Osteoclasts: what do they do and how do they do it?
- Prof. Steven L. Teitelbaum
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8. The biology of Fc receptors and complement receptors
- Prof. Steven Greenberg
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10. Tumour-associated macrophages
- Prof. Michele De Palma
- Dr. Mario Squadrito
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11. The recognition of pathogens by C-type lectins
- Prof. Gordon D. Brown
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12. Macrophage phagocytosis
- Prof. Joel Swanson
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13. Macrophage CD36 and atherosclerosis
- Dr. Maria Febbraio
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14. Toll-Like receptor signaling and the innate immune response
- Dr. Kate Fitzgerald
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15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria
- Prof. Ricardo Gazzinelli
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17. Triggering receptors expressed on myeloid cells (TREM)
- Dr. Daniel W. McVicar
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18. Influence of eicosanoid lipid mediators on macrophage innate immune functions
- Prof. Marc Peters-Golden
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19. Macrophage paired receptor interactions
- Prof. Neil Barclay
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20. Macrophage heterogeneity in atherosclerosis regression
- Prof. Edward Fisher
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21. Gaucher disease: from lysosomal storage to immunopathology
- Prof. Johannes M.F.G. Aerts
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22. Macrophage in asthma
- Prof. Douglas Robinson
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23. The macrophage mannose receptor
- Dr. Luisa Martinez-Pomares
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24. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
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25. EGF-TM7 receptors
- Dr. Jörg Hamann
- Dr. Hsi-Hsien Lin
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26. Macrophages in helminth infection
- Prof. Judith Allen
- Archived Lectures *These may not cover the latest advances in the field
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27. Immunosuppressive mechanisms in myeloid cells
- Prof. Dmitry Gabrilovich
Printable Handouts
Navigable Slide Index
- Introduction
- Recognising an invading organism
- Recognising PAMPS
- Research in flies
- TLRs
- TLR sensing pathogens
- C-type lectin domain (CTLD)
- CTLD groups
- CTLD specific groups
- MBL
- MBL functions
- MBL attack
- MBL: intracellular signalling
- Is MBL important?
- Surfactant proteins
- Surfactant proteins: functions
- Triggering inhibitory intracellular signals
- Are surfactant proteins important?
- The membrane bound mannose receptor
- The mannose receptor (MR) structure
- The mannose receptor (MR) recognition
- The role of the mannose receptor
- Is the mannose receptor important?
- DC-SIGN
- DC-SIGN structure and recognition
- Mannose-specific DC-SIGN signalling
- Fucose-specific DC-SIGN signalling
- Is DC-SIGN important?
- Dectin-1
- Dectin-1 structure
- Dectin-1 crystal structure
- Dectin-1 recognition
- Particle uptake in Dectin-1 transfected cells
- Innate responses mediated by Dectin-1
- Dectin-1 recognises live fungal pathogens
- Dectin-1 non-redundant role in antifungal immunity
- Role of Dectin-1 in anti-fungal immunity: mouse
- Human Dectin-1 polymorphism
- Human Dectin-1 deficiency
- Role of Dectin-1 in anti-fungal immunity: human
- Role of Dectin-1 in adaptive immunity
- Dectin-1 mediated intracellular signalling
- Syk kinase
- Dectin-1 triggers Raf-1 pathway
- Dectin-1 signalling
- Dectin-1 signalling for cytokine production
- Collaborative signalling for cytokine production
- Dectin-1 and TLR-2 are required for TNF induction
- Chromoblastomycosis and Fonsecaea pedrosoi
- Co-stimulation in vitro
- Reason for chronic infection
- Restoring inflammatory response
- Repression of other cytokines
- Co-stimulation affects type of adaptive response
- Dectin-1 similarity to TLR
- Dectin-2 and Mincle
- Dectin-2
- Is Dectin-2 important?
- Mincle
- Dectin-1, Dectin-2 and Mincle similarity to TLR
- Pathogens recognised by Dectin-2/Mincle
- Th17 responses and fungal infections
- Summary
- Acknowledgements
Topics Covered
- Role of pattern recognition receptors in extracellular pathogen recognition
- TLR and CLR
- Soluble CLRs and opsonisation
- MBL, SPA, SPD
- Membrane CLRs and signal transduction
- Mannose Receptor
- DC-SIGN
- Dectin-1
- Dectin-2
- MINCLE
- Innate and adaptive immune responses
Links
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Talk Citation
Brown, G.D. (2012, May 8). The recognition of pathogens by C-type lectins [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 5, 2024, from https://doi.org/10.69645/BDCV3646.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Gordon Brown is supported by Wellcome Trust, MRC Centre for Medical Mycology and NIHR Exeter Biomedical Research Centre.