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- Clinical Introduction
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1. Frontotemporal dementia
- Prof. Bruce Miller
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2. Parkinson disease
- Prof. Stanley Fahn
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3. Atypical parkinsonian syndromes
- Dr. David Burn
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4. Huntington's disease
- Prof. Roger Barker
- Neuroimaging
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5. Molecular brain imaging (PET) in diseases with dementia
- Prof. Karl Herholz
- Pathology, Genetic and Molecular Aspects (1)
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6. A molecular understanding of Alzheimer's disease
- Prof. John Hardy
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7. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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9. Ubiquitination and Alzheimer related disorders
- Prof. John Mayer
- Pathology, Genetic and Molecular Aspects (2)
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10. The molecular biology of Huntington's disease
- Prof. David C. Rubinsztein
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11. Metals, oxidative stress and neurodegeneration
- Prof. Ashley Bush
- Latest Developments in the Field
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12. Animal models of tauopathy
- Prof. David Westaway
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13. Parkinson's disease and transplants
- Prof. Roger Barker
- Archived Lectures *These may not cover the latest advances in the field
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14. Neuropathology of neurodegenerative disorders
- Prof. Jillian Kril
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15. Motor neurone disease: molecular basis
- Prof. Kevin Talbot
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16. Alzheimer's disease (AD)
- Prof. John Hodges
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17. Frontotemporal dementia syndromes
- Prof. John Hodges
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18. Motor neurone disease: clinical aspects
- Prof. Kevin Talbot
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19. Neuro-imaging in dementia: using MRI in routine work-up
- Prof. Philip Scheltens
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20. Prion diseases
- Prof. Pierluigi Gambetti
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21. Mitochondrial disorders and neurodegeneration
- Prof. Anthony Schapira
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23. Mutations in parkinsonian syndromes
- Dr. Andrew Singleton
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25. Frontotemporal dementia
- Prof. Bruce Miller
Printable Handouts
Navigable Slide Index
- Intro slide
- Human prion diseases - classification
- Prion disease - animals
- Outline
- Prion protein (PrP) - hamster
- Prion protein - normal processing
- Prion protein - membrane association
- Normal Prp and PrP(C) 3D-structure
- Proposed biological functions of normal PrP
- Pathogenesis of prion diseases
- PrP(C) and PrP(Sc)/PrP(res) 3D-structure
- Possible mechanism of PrP propagation
- PrP propagation in familial forms
- PrP propagation in acquired form
- Pathogenetic hypotheses
- Prion protein (PrP) - hamster
- Immunoblotting of PrP(C) and PrP(Sc)
- Immunoblot analysis (case 1 brain biopsy)
- Human prion diseases - inherited
- Human PrP - pathogenic mutations/polymorphisms
- Human prion diseases - sporadic
- Variants of sCJD
- Human PrP gene - codon 129 polymorphism
- Immunoblotting of PrP(C) and PrP(Sc)
- Classification of sporadic CJD - 300 subjects
- Codon 129 alleles and PrP(Sc) types
- Classification of sporadic prion diseases
- Microscopic view of cerebral cortex
- sCJDMV2 - only sCJD subtype with kuru plaques
- PrP immunostain - cerebral cortex
- 14-3-3 test sensitivity and PrP(Sc) type/phenotype
- Human prion diseases - acquired by infection
- Iatrogenic CJDs
- BSE and vCJD epidemics
- Variant CJD (1)
- Variant CJD (2)
- Variant CJD - "fluorid plaque"
- PrP immunostain - variant/sporadic CJD
- The problem of CWD in the USA
- Prion diseases - treatment
- Prion research collaborators
Topics Covered
- Normal function of prion protein
- Prion diseases
- Mechanism of propagation of PrP
- Propagation in acquired and familial forms
- Pathogenic hypothesis
- Human pathogenic mutation and polymorphisms
- Laboratory methods
- Epidemiology
- Sporadic prion diseases
- New variant CJD
- Treatment of prion disease
Links
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Talk Citation
Gambetti, P. (2007, October 1). Prion diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/YUMX8129.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Pierluigi Gambetti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.