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1. Introduction
2. Osteoblasts and osteoclasts
3. Osteoclasts (1)
4. Osteoporosis (1)
5. Osteoporosis (2)
6. Bone remodeling (1)
7. Bone remodeling (2)
8. Bone remodeling (3)
9. Bone remodeling (4)
10. Osteoporosis (3)
11. Osteopetrosis
12. Osteopetrosis X-ray
13. Increased bone mass and osteopetrosis
14. Clinical forms of osteopetrosis
15. Malignant osteopetrosis
16. A patient with osteopetrosis
17. Transplantation result
18. Patient at the age of 3
19. Patient at adulthood
20. What is the osteoclast precursor?
21. Hematopoietic precursor or stromal cell origin?
22. Y-chromosome
23. Y-body analysis of osteoclasts and osteoblasts
24. The osteoclast precursor
25. Osteoclast differentiation (1)
26. Osteoprotogerin
27. Osteoclast differentiation (2)
28. RANK ligand gene deletion
29. Osteoclast differentiation (3)
30. Osteoclasts generated in vitro
31. Osteoclastogenic signals
32. Osteoclast differentiation and function (1)
33. How does the osteoclast degrade bone?
34. Isolated micro-environment formation
35. Osteoclast proton pump
36. Osteoclast proton pump mutation
37. Osteoclast differentiation and function (2)
38. Carbonic anhydrase
39. Family with benign osteopetrosis
40. Carbonic anhydrase deficiency
41. Osteoclast differentiation and function (3)
42. Osteoclast PH changes
43. In the presence of Cl-
44. Cl-/HCO3- exchange (1)
45. Cl-/HCO3- exchange (2)
46. SLC4A2- anion exchanger
47. Osteoclast differentiation and function (4)
48. Anion access
49. Osteoclast chloride channel
50. Bone resorption mechanism
51. Chloride channel and osteopetrosis
52. Osteoclast differentiation and function (5)
53. Bone = mineral + organic matrix
54. Organic matrix degrading enzyme
55. Cathepsin K
56. Pyknodysostosis
57. Osteoclast differentiation and function (6)
58. Osteoclast-bone attachment mechanism
59. Integrin-matrix attachment (1)
60. Integrin family
61. Beta3-/- mice are osteopetrotic (1)
62. Beta3-/- mice are osteopetrotic (2)
63. The effect of integrin deletion on osteoclasts
64. Osteoclast cytoskeleton
65. Podosome
66. Actin ring
67. Osteoclast E/M
68. Clues to the formation of the ruffled border (1)
69. Clues to the formation of the ruffled border (2)
70. Formation of the ruffled border-mechanism
71. Synaptotagmins (Syt)
72. Does SytVII organize the ruffled border?
73. SytVII-/- osteoclasts have abnormal ruffled border
74. SytVII-/- osteoclasts resorb bone poorly
75. Integrin-matrix attachment (2)
76. Integrin organizes the osteoclast cytoskeleton
77. Summary
78. Osteoclast differentiation and function (7)

Topics Covered

• Osteoclast
• Osteoporosis
• Bone remodeling
• Osteopetrosis
• Mechanisms of osteoclast formation
• Mechanisms of osteoclastic bone resorption
• Osteoclast cytoskeleton

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Teitelbaum, S.L. (2012, May 8). Osteoclasts: what do they do and how do they do it? [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/NVQU7046.
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Publication History

• Published on May 8, 2012

Financial Disclosures

• Prof. Steven L. Teitelbaum has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.