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• 68 min
  1. The mononuclear phagocyte system: tissue resident macrophages - activation and regulation

  • Prof. Emeritus Siamon Gordon
• 25 min
  2. Biosimilars: when value meets cost

  • Prof. Fernando de Mora
• 25 min
  3. Mononuclear phagocytes - origins, fates and functions

  • Prof. Steffen Jung
• 39 min
  4. Transcription factors in macrophage differentiation

  • Dr. Michael Sieweke
• 44 min
  5. Fetal macrophages

  • Prof. Paul Martin
• 44 min
  6. The alveolar macrophage

  • Dr. Ronald G. Crystal
• 35 min
  7. Airway macrophages in health and disease

  • Prof. Tracy Hussell
• 65 min
  8. Intestinal macrophages - heterogeneity, origins and functions

  • Prof. Allan Mowat
• 27 min
  9. Osteoclasts: what do they do and how do they do it?

  • Prof. Steven L. Teitelbaum
• 51 min
  10. The biology of Fc receptors and complement receptors

  • Prof. Steven Greenberg
• 71 min
  11. A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair

  • Prof. Michal Schwartz
• 38 min
  12. Tumour-associated macrophages

  • Prof. Michele De Palma
  • Dr. Mario Squadrito
• 42 min
  13. The recognition of pathogens by C-type lectins

  • Prof. Gordon D. Brown
• 34 min
  14. Macrophage phagocytosis

  • Prof. Joel Swanson
• 30 min
  15. Macrophage CD36 and atherosclerosis

  • Dr. Maria Febbraio
• 31 min
  16. Toll-Like receptor signaling and the innate immune response

  • Dr. Kate Fitzgerald
• 43 min
  17. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria

  • Prof. Ricardo Gazzinelli
• 34 min
  18. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions in cellular interactions

  • Prof. Eric Vivier
• 69 min
  19. Triggering receptors expressed on myeloid cells (TREM)

  • Dr. Daniel W. McVicar
• 60 min
  20. Influence of eicosanoid lipid mediators on macrophage innate immune functions

  • Prof. Marc Peters-Golden
• 47 min
  21. Macrophage paired receptor interactions

  • Prof. Neil Barclay
• 45 min
  22. Macrophage heterogeneity in atherosclerosis regression

  • Prof. Edward Fisher
• 35 min
  23. Gaucher disease: from lysosomal storage to immunopathology

  • Prof. Johannes M.F.G. Aerts
• 26 min
  24. Macrophage in asthma

  • Prof. Douglas Robinson
• 51 min
  25. The macrophage mannose receptor

  • Dr. Luisa Martinez-Pomares
• 41 min
  26. Myeloid-derived suppressor cells in cancer

  • Prof. Dmitry Gabrilovich
• 29 min
  27. EGF-TM7 receptors

  • Dr. Jörg Hamann
  • Dr. Hsi-Hsien Lin
• 37 min
  28. Macrophages in helminth infection

  • Prof. Judith Allen
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  29. Immunosuppressive mechanisms in myeloid cells

  • Prof. Dmitry Gabrilovich

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Antigenic challenge in intestine
3. Prevention of intestinal inflammation (1)
4. Prevention of intestinal inflammation (2)
5. Intestinal macrophages
6. Resting colonic F4/80+ cells activated phenotype
7. No proinflammatory cytokines in F4/80+ cells
8. All that is F4/80+ is not a macrophage
9. CX3CR1 defines colonic macrophage subsets
10. CX3CR1 defines colonic macrophage functions
11. Colonic macrophages in inflammation
12. Phenotypic comparison of mouse macrophages
13. Macrophage differentiation: context dependent (1)
14. Intestinal macrophage differentiation in situ? (1)
15. Intestinal macrophage differentiation in situ? (2)
16. Intestinal macrophage differentiation in situ? (3)
17. Monocyte origin of resident colonic macrophages
18. Ly6C-hi monocytes in steady state colon
19. Control of colonic macrophage development
20. CD200R1 does not regulate colonic macrophages
21. IL10 & regulation of resident colonic macrophages
22. Macrophage differentiation: context dependent (2)
23. Macrophages and inflammatory bowel disease
24. TNFalpha & macrophages in acute colitis
25. Colonic macrophage subsets in inflammation
26. Cytokine production by macrophages in colitis
27. Generation of macrophages in colitis
28. Intestinal macrophage subsets in mice
29. Intestinal macrophage subsets in humans
30. Intestinal macrophages in health and disease
31. Intestinal macrophages in regulatory T cell function
32. Acknowledgments

Topics Covered

• Macrophages play essential roles in both homeostasis and inflammation in the intestine
• Distinct populations of macrophages control each of these functions
• Novel strategies for characterizing mouse intestinal macrophages
• A single population of monocyte gives rise to both resident and inflammatory macrophages in intestine
• Actions of macrophages in healthy intestine in mice
• Actions of macrophages in inflamed intestine in mice
• Similar processes in humans
• Application of knowledge of macrophages to human diseases including Crohn's disease

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on August 28, 2012

Financial Disclosures

• Prof. Allan Mowat has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.