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1. Mononuclear phagocytes - origins, fates and functions
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2. Transcription factors in macrophage differentiation
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3. Fetal macrophages
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4. The alveolar macrophage
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5. Airway macrophages in health and disease
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6. Intestinal macrophages - heterogeneity, origins and functions
- Prof. Allan Mowat
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7. Osteoclasts: what do they do and how do they do it?
- Prof. Steven L. Teitelbaum
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8. The biology of Fc receptors and complement receptors
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10. Tumour-associated macrophages
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11. The recognition of pathogens by C-type lectins
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12. Macrophage phagocytosis
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13. Macrophage CD36 and atherosclerosis
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14. Toll-Like receptor signaling and the innate immune response
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17. Triggering receptors expressed on myeloid cells (TREM)
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18. Influence of eicosanoid lipid mediators on macrophage innate immune functions
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19. Macrophage paired receptor interactions
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20. Macrophage heterogeneity in atherosclerosis regression
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21. Gaucher disease: from lysosomal storage to immunopathology
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22. Macrophage in asthma
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23. The macrophage mannose receptor
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24. Myeloid-derived suppressor cells in cancer
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25. EGF-TM7 receptors
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26. Macrophages in helminth infection
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27. Immunosuppressive mechanisms in myeloid cells
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Printable Handouts
Navigable Slide Index
- Introduction
- Antigenic challenge in intestine
- Prevention of intestinal inflammation (1)
- Prevention of intestinal inflammation (2)
- Intestinal macrophages
- Resting colonic F4/80+ cells activated phenotype
- No proinflammatory cytokines in F4/80+ cells
- All that is F4/80+ is not a macrophage
- CX3CR1 defines colonic macrophage subsets
- CX3CR1 defines colonic macrophage functions
- Colonic macrophages in inflammation
- Phenotypic comparison of mouse macrophages
- Macrophage differentiation: context dependent (1)
- Intestinal macrophage differentiation in situ? (1)
- Intestinal macrophage differentiation in situ? (2)
- Intestinal macrophage differentiation in situ? (3)
- Monocyte origin of resident colonic macrophages
- Ly6C-hi monocytes in steady state colon
- Control of colonic macrophage development
- CD200R1 does not regulate colonic macrophages
- IL10 & regulation of resident colonic macrophages
- Macrophage differentiation: context dependent (2)
- Macrophages and inflammatory bowel disease
- TNFalpha & macrophages in acute colitis
- Colonic macrophage subsets in inflammation
- Cytokine production by macrophages in colitis
- Generation of macrophages in colitis
- Intestinal macrophage subsets in mice
- Intestinal macrophage subsets in humans
- Intestinal macrophages in health and disease
- Intestinal macrophages in regulatory T cell function
- Acknowledgments
Topics Covered
- Macrophages play essential roles in both homeostasis and inflammation in the intestine
- Distinct populations of macrophages control each of these functions
- Novel strategies for characterizing mouse intestinal macrophages
- A single population of monocyte gives rise to both resident and inflammatory macrophages in intestine
- Actions of macrophages in healthy intestine in mice
- Actions of macrophages in inflamed intestine in mice
- Similar processes in humans
- Application of knowledge of macrophages to human diseases including Crohn's disease
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Talk Citation
Mowat, A. (2012, August 28). Intestinal macrophages - heterogeneity, origins and functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/MPAN5446.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Allan Mowat has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.